{"id":553,"date":"2023-04-21T08:55:23","date_gmt":"2023-04-21T06:55:23","guid":{"rendered":"http:\/\/immunotherapy.gr\/?page_id=553"},"modified":"2024-03-20T20:12:48","modified_gmt":"2024-03-20T18:12:48","slug":"%ce%b1%cf%86%cf%83","status":"publish","type":"page","link":"https:\/\/immunotherapy.gr\/?page_id=553","title":{"rendered":"\u0391\u03a6\u03a3"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; admin_label=&#8221;Hero&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; custom_padding=&#8221;0|0px|54px|0px|false|false&#8221; bottom_divider_height=&#8221;0px&#8221; border_width_bottom=&#8221;1px&#8221; border_color_bottom=&#8221;#efefef&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row column_structure=&#8221;1_2,1_2&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; width=&#8221;100%&#8221; max_width=&#8221;100%&#8221; custom_margin=&#8221;|||&#8221; custom_margin_tablet=&#8221;||0px|&#8221; 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inline_fonts=&#8221;Arial,Archivo Black&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p><span style=\"font-family: Arial; font-weight: normal;\"><strong>\u0391\u03bd\u03c4\u03b9\u03c6\u03c9\u03c3\u03c6\u03bf\u03bb\u03b9\u03c0\u03b9\u03b4\u03b9\u03ba\u03cc \u03a3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf-\u0392\u03b1\u03c3\u03b9\u03ba\u03ad\u03c2 \u03b3\u03bd\u03ce\u03c3\u03b5\u03b9\u03c2\u00a0<\/strong><\/span><\/p>\n<p><span style=\"font-weight: normal; font-family: Arial;\">\u0391\u03bd\u03c4\u03ce\u03bd\u03b9\u03bf\u03c2 \u0394. \u0393\u03b5\u03c1\u03bf\u03c6\u03ce\u03c4\u03b7\u03c2, \u0391\u03b9\u03bc\u03b1\u03c4\u03bf\u03bb\u03cc\u03b3\u03bf\u03c2, \u0391\u03b9\u03bc\u03b1\u03b3\u03ad\u03bd\u03b5\u03c3\u03b9\u03c2 \u0391\u03b9\u03bc\u03b1\u03c4\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u0399\u03b1\u03c4\u03c1\u03b5\u03af\u03bf, \u0398\u03b5\u03c3\u03c3\u03b1\u03bb\u03bf\u03bd\u03af\u03ba\u03b7, \u03a4\u03c3\u03b9\u03bc\u03b9\u03c3\u03ba\u03ae 111, 54622, \u03c4\u03b7\u03bb. 6934842568, email amedigerf@gmail.com<\/span><\/p>\n<p><span style=\"font-weight: normal; font-family: Arial;\">\u039c\u03b9\u03c7\u03b1\u03ae\u03bb \u0391\u03bb. \u0394\u03b1\u03bd\u03b9\u03b7\u03bb\u03af\u03b4\u03b7\u03c2, \u039f\u03bc. \u039a\u03b1\u03b8\u03b7\u03b3\u03b7\u03c4\u03ae\u03c2 \u03a0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03af\u03b1\u03c2-\u0391\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03af\u03b1\u03c2 \u0391\u03a0\u0398, \u0398\u03b5\u03c3\u03c3\u03b1\u03bb\u03bf\u03bd\u03af\u03ba\u03b7<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span><\/span><\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_image src=&#8221;https:\/\/immunotherapy.gr\/wp-content\/uploads\/2022\/12\/doctor-14.jpg&#8221; force_fullwidth=&#8221;on&#8221; align_tablet=&#8221;center&#8221; align_phone=&#8221;center&#8221; align_last_edited=&#8221;on|desktop&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;|||&#8221; custom_padding=&#8221;|||&#8221; animation_style=&#8221;slide&#8221; animation_direction=&#8221;right&#8221; animation_intensity_slide=&#8221;5%&#8221; border_radii=&#8221;||||30vw&#8221; border_color_all=&#8221;#0ee1f4&#8243; border_width_left=&#8221;2vw&#8221; border_color_left=&#8221;#37dfff&#8221; box_shadow_style=&#8221;preset4&#8243; box_shadow_horizontal=&#8221;-30px&#8221; box_shadow_vertical=&#8221;0px&#8221; box_shadow_color=&#8221;rgba(14,225,244,0.33)&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=&#8221;4.17.4&#8243; _module_preset=&#8221;default&#8221;][et_pb_column _builder_version=&#8221;4.17.4&#8243; _module_preset=&#8221;default&#8221; type=&#8221;4_4&#8243;][et_pb_text _builder_version=&#8221;4.17.4&#8243; _module_preset=&#8221;default&#8221; text_font=&#8221;Arial||||||||&#8221; hover_enabled=&#8221;0&#8243; sticky_enabled=&#8221;0&#8243;]<\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: Arial; font-weight: normal;\"><strong>\u03a0\u03b5\u03c1\u03af\u03bb\u03b7\u03c8\u03b7<\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-weight: 400;\">\u039c\u03b5 \u03c4\u03bf\u03bd \u03cc\u03c1\u03bf \u03b8\u03c1\u03bf\u03bc\u03b2\u03bf\u03c6\u03b9\u03bb\u03af\u03b1 (\u03b5\u03c4\u03c5\u03bc. \u201c\u03c6\u03b9\u03bb\u03b5\u03af \u03b8\u03c1\u03cc\u03bc\u03b2\u03bf\u201d) \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b7 \u03c4\u03ac\u03c3\u03b7 \u03b5\u03bd\u03cc\u03c2 \u03bf\u03c1\u03b3\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03cd \u03bd\u03b1 \u03b5\u03ba\u03b4\u03b7\u03bb\u03ce\u03c3\u03b5\u03b9 \u03ad\u03bd\u03b1 \u03b8\u03c1\u03bf\u03bc\u03b2\u03c9\u03c4\u03b9\u03ba\u03cc \u03b5\u03c0\u03b5\u03b9\u03c3\u03cc\u03b4\u03b9\u03bf. \u03a4\u03bf \u03b1\u03bd\u03c4\u03b9\u03c6\u03c9\u03c3\u03c6\u03bf\u03bb\u03b9\u03c0\u03b9\u03b4\u03b9\u03ba\u03cc \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf (\u0391\u03a6\u03a3) \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b9\u03b1 \u03b5\u03c0\u03af\u03ba\u03c4\u03b7\u03c4\u03b7 \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03b7 \u03b1\u03b9\u03c4\u03af\u03b1 \u03b5\u03c0\u03af\u03ba\u03c4\u03b7\u03c4\u03b7\u03c2 \u03b8\u03c1\u03bf\u03bc\u03b2\u03bf\u03c6\u03b9\u03bb\u03af\u03b1\u03c2, \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1 \u03b1\u03bd\u03c4\u03b9\u03c6\u03c9\u03c3\u03c6\u03bf\u03bb\u03b9\u03c0\u03b9\u03b4\u03b9\u03ba\u03ce\u03bd \u03b1\u03bd\u03c4\u03b9\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd <span style=\"font-family: Arial; font-weight: normal;\">(aPL)<\/span> \u03c3\u03c4\u03bf\u03bd \u03bf\u03c1\u03cc \u03c4\u03c9\u03bd \u03c0\u03b1\u03c3\u03c7\u03cc\u03bd\u03c4\u03c9\u03bd, \u03ba\u03b1\u03b8\u03ce\u03c2 \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03ba\u03b9 \u03b1\u03c0\u03cc \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ac \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac \u03b8\u03c1\u03cc\u03bc\u03b2\u03c9\u03c3\u03b7\u03c2 \u03c6\u03bb\u03b5\u03b2\u03b9\u03ba\u03ae\u03c2, \u03b1\u03c1\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ae\u03c2, \u03c4\u03c9\u03bd \u03bc\u03b9\u03ba\u03c1\u03ce\u03bd \u03b1\u03b3\u03b3\u03b5\u03af\u03c9\u03bd \u03ba\u03b1\u03b9 \u03b1\u03c0\u03cc \u03bd\u03bf\u03c3\u03b7\u03c1\u03cc\u03c4\u03b7\u03c4\u03b1 \u03ba\u03cd\u03b7\u03c3\u03b7\u03c2. \u039f\u03b9 \u03c3\u03c5\u03bd\u03b7\u03b8\u03ad\u03c3\u03c4\u03b5\u03c1\u03b1 \u03b1\u03bd\u03b9\u03c7\u03bd\u03b5\u03c5\u03bc\u03ad\u03bd\u03b5\u03c2 \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ac \u03ba\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03af\u03b5\u03c2 \u03b1\u03bd\u03c4\u03b9\u03c6\u03c9\u03c3\u03c6\u03bf\u03bb\u03b9\u03c0\u03b9\u03b4\u03b9\u03ba\u03ce\u03bd \u03b1\u03bd\u03c4\u03b9\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd <span style=\"font-family: Arial; font-weight: normal;\">aPL<\/span> \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03b1 \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03c4\u03cd\u03c0\u03bf\u03c5 \u03b1\u03bd\u03c4\u03b9\u03c0\u03b7\u03ba\u03c4\u03b9\u03ba\u03bf\u03cd \u03c4\u03bf\u03c5 \u03bb\u03cd\u03ba\u03bf\u03c5 (<span style=\"font-family: Arial; font-weight: normal;\">Lupus Anticoagulant &#8211; LA<\/span>), \u03c4\u03b1 \u03b1\u03bd\u03c4\u03b9\u03ba\u03b1\u03c1\u03b4\u03b9\u03bf\u03bb\u03b9\u03c0\u03b9\u03bd\u03b9\u03ba\u03ac (<span style=\"font-family: Arial; font-weight: normal;\">anti &#8211; Cardiolipin &#8211; aCL<\/span>) \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03b1 \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03c4\u03b7\u03c2 \u03b22 \u03b3\u03bb\u03c5\u03ba\u03bf\u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7\u03c2 \u0399 (<span style=\"font-family: Arial;\">Anti-\u03b22-GPI antibodies<\/span>). \u039f\u03b9 \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03af \u03c0\u03bf\u03c5 \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03ad\u03c7\u03bf\u03c5\u03bd \u03c3\u03c4\u03b7\u03bd \u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ae \u03b8\u03c1\u03cc\u03bc\u03b2\u03c9\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c4\u03b9\u03c2 \u03b1\u03c5\u03c4\u03cc\u03bc\u03b1\u03c4\u03b5\u03c2 \u03b1\u03c0\u03bf\u03b2\u03bf\u03bb\u03ad\u03c2 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03b1\u03bd\u03c4\u03b9\u03c6\u03c9\u03c3\u03c6\u03bf\u03bb\u03b9\u03c0\u03b9\u03b4\u03b9\u03ba\u03cc \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf \u03b4\u03b5\u03bd \u03ad\u03c7\u03bf\u03c5\u03bd \u03b1\u03ba\u03cc\u03bc\u03b7 \u03c0\u03bb\u03ae\u03c1\u03c9\u03c2 \u03b4\u03b9\u03b5\u03c5\u03ba\u03c1\u03b9\u03bd\u03b9\u03c3\u03c4\u03b5\u03af, \u03c9\u03c3\u03c4\u03cc\u03c3\u03bf \u03c0\u03c1\u03bf\u03c4\u03b5\u03af\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9\u00a0\u03b4\u03b9\u03ac\u03c6\u03bf\u03c1\u03bf\u03b9 \u03c0\u03b1\u03b8\u03bf\u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03bf\u03af \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03af \u03c0\u03bf\u03c5 \u03c5\u03c0\u03b1\u03b3\u03bf\u03c1\u03b5\u03cd\u03bf\u03c5\u03bd \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b5\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c3\u03c4\u03c1\u03b1\u03c4\u03b7\u03b3\u03b9\u03ba\u03ad\u03c2.<\/span><\/p>\n<p style=\"text-align: justify;\"><b>\u039b\u03ad\u03be\u03b5\u03b9\u03c2 \u03b5\u03c5\u03c1\u03b5\u03c4\u03b7\u03c1\u03af\u03bf\u03c5<\/b><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-weight: 400;\">\u03b1\u03bd\u03c4\u03b9\u03c6\u03c9\u03c3\u03c6\u03bf\u03bb\u03b9\u03c0\u03b9\u03b4\u03b9\u03ba\u03cc \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf, \u03ba\u03b1\u03b8&#8217;\u03ad\u03be\u03b9\u03bd \u03b1\u03c0\u03bf\u03b2\u03bf\u03bb\u03ad\u03c2, \u03b8\u03c1\u03bf\u03bc\u03b2\u03bf\u03c6\u03b9\u03bb\u03af\u03b1, \u03b1\u03bd\u03c4\u03b9\u03c0\u03b7\u03ba\u03c4\u03b9\u03ba\u03cc \u03c4\u03bf\u03c5 \u03bb\u03cd\u03ba\u03bf\u03c5, \u03b1\u03bd\u03c4\u03b9\u03ba\u03b1\u03c1\u03b4\u03b9\u03bf\u03bb\u03b9\u03c0\u03b9\u03bd\u03b9\u03ba\u03ac \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-weight: 400;\"><\/span><\/p>\n<p style=\"text-align: justify;\">\n<p style=\"text-align: justify;\"><b>\u0391\u03bd\u03c4\u03b9\u03c6\u03c9\u03c3\u03c6\u03bf\u03bb\u03b9\u03c0\u03b9\u03b4\u03b9\u03ba\u03cc \u03a3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf<\/b><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-weight: 400;\">\u03a4\u03bf \u03b1\u03bd\u03c4\u03b9\u03c6\u03c9\u03c3\u03c6\u03bf\u03bb\u03b9\u03c0\u03b9\u03b4\u03b9\u03ba\u03cc \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf (APS), \u03b3\u03bd\u03c9\u03c3\u03c4\u03cc \u03ba\u03b1\u03b9 \u03c9\u03c2 \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf Hughes, \u03c0\u03b5\u03c1\u03b9\u03b3\u03c1\u03ac\u03c6\u03b7\u03ba\u03b5 \u03b3\u03b9\u03b1 \u03c0\u03c1\u03ce\u03c4\u03b7 \u03c6\u03bf\u03c1\u03ac \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd Graham Hughes, \u03c3\u03c4\u03bf Hammersmith Hospital, \u03c4o 1983. \u03a0\u03c1\u03cc\u03ba\u03b5\u03b9\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03bc\u03af\u03b1 \u03c0\u03c1\u03bf\u03b8\u03c1\u03bf\u03bc\u03b2\u03c9\u03c4\u03b9\u03ba\u03ae \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ae \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03bf\u03c5 \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03ae\u03c1\u03b1 \u03bc\u03b5 \u03b5\u03ba\u03b4\u03b7\u03bb\u03ce\u03c3\u03b5\u03b9\u03c2 \u03c4\u03cc\u03c3\u03bf \u03b1\u03c0\u03cc \u03c4\u03b7 \u03c6\u03bb\u03b5\u03b2\u03b9\u03ba\u03ae \u03cc\u03c3\u03bf \u03ba\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03b1\u03c1\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ae \u03ba\u03c5\u03ba\u03bb\u03bf\u03c6\u03bf\u03c1\u03af\u03b1 \u03ae\/\u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03b1\u03c0\u03bf\u03c4\u03c5\u03c7\u03b7\u03bc\u03ad\u03bd\u03b7 \u03ad\u03ba\u03b2\u03b1\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03ba\u03cd\u03b7\u03c3\u03b7\u03c2 \u03bc\u03b5 \u03c4\u03b1\u03c5\u03c4\u03cc\u03c7\u03c1\u03bf\u03bd\u03b7 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1 \u03b1\u03bd\u03c4\u03b9\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03ce\u03bd \u03c4\u03bf\u03c5 \u03c0\u03bb\u03ac\u03c3\u03bc\u03b1\u03c4\u03bf\u03c2 \u03c0\u03bf\u03c5 \u03c3\u03c5\u03bd\u03b4\u03ad\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c6\u03c9\u03c3\u03c6\u03bf\u03bb\u03b9\u03c0\u03af\u03b4\u03b9\u03b1<\/span><span style=\"font-weight: 400;\"> (\u03b1\u03bd\u03c4\u03b9\u03c6\u03c9\u03c3\u03c6\u03bf\u03bb\u03b9\u03c0\u03b9\u03b4\u03b9\u03ba\u03ce\u03bd \u03b1\u03bd\u03c4\u03b9\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd aPL)<\/span><span style=\"font-weight: 400;\">. \u0394\u03b9\u03b1\u03ba\u03c1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03c0\u03c1\u03c9\u03c4\u03bf\u03c0\u03b1\u03b8\u03ad\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03b5 \u03b4\u03b5\u03c5\u03c4\u03b5\u03c1\u03bf\u03c0\u03b1\u03b8\u03ad\u03c2. \u03a3\u03c4\u03bf \u03c0\u03c1\u03c9\u03c4\u03bf\u03c0\u03b1\u03b8\u03ad\u03c2 \u03b4\u03b5\u03bd \u03b1\u03bd\u03b5\u03c5\u03c1\u03af\u03c3\u03ba\u03b5\u03c4\u03b1\u03b9 \u03ba\u03b1\u03bd\u03ad\u03bd\u03b1 \u03c5\u03c0\u03bf\u03ba\u03b5\u03af\u03bc\u03b5\u03bd\u03bf \u03b1\u03af\u03c4\u03b9\u03bf, \u03b5\u03bd\u03ce \u03b4\u03b5\u03c5\u03c4\u03b5\u03c1\u03bf\u03c0\u03b1\u03b8\u03ce\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b1\u03bd\u03b1\u03c0\u03c4\u03c5\u03c7\u03b8\u03b5\u03af \u03b5\u03c0\u03af \u03b5\u03b4\u03ac\u03c6\u03bf\u03c5\u03c2 \u03c0\u03bf\u03b9\u03ba\u03af\u03bb\u03c9\u03bd \u03bd\u03bf\u03c3\u03b7\u03bc\u03ac\u03c4\u03c9\u03bd, \u03cc\u03c0\u03c9\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf\u03b9 \u03c1\u03b5\u03c5\u03bc\u03b1\u03c4\u03bf\u03c0\u03ac\u03b8\u03b5\u03b9\u03b5\u03c2, \u03c4\u03b1 \u03bd\u03b5\u03bf\u03c0\u03bb\u03ac\u03c3\u03bc\u03b1\u03c4\u03b1, \u03bf\u03b9 \u03bb\u03bf\u03b9\u03bc\u03ce\u03be\u03b5\u03b9\u03c2 (\u03c0.\u03c7. HIV, CMV, \u03c3\u03cd\u03c6\u03b9\u03bb\u03b7, \u03b7\u03c0\u03b1\u03c4\u03af\u03c4\u03b9\u03b4\u03b1, \u03b5\u03bb\u03bf\u03bd\u03bf\u03c3\u03af\u03b1, \u03bc\u03c5\u03ba\u03cc\u03c0\u03bb\u03b1\u03c3\u03bc\u03b1) \u03ae \u03c6\u03b1\u03c1\u03bc\u03b1\u03ba\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b1\u03b3\u03c9\u03b3\u03ae (\u03c7\u03bb\u03c9\u03c1\u03bf\u03c0\u03c1\u03bf\u03bc\u03b1\u03b6\u03af\u03bd\u03b7, \u03c5\u03b4\u03c1\u03b1\u03bb\u03b1\u03b6\u03af\u03bd\u03b7, \u03c0\u03c1\u03bf\u03ba\u03b1\u03ca\u03bd\u03b1\u03bc\u03af\u03b4\u03b7, \u03c6\u03b1\u03b9\u03bd\u03c5\u03bd\u03c4\u03bf\u03ca\u03bd\u03b7, \u03b9\u03bd\u03c4\u03b5\u03c1\u03c6\u03b5\u03c1\u03cc\u03bd\u03b7, \u03ba\u03b9\u03bd\u03af\u03bd\u03b7, \u03b1\u03bc\u03bf\u03be\u03c5\u03ba\u03b9\u03bb\u03bb\u03af\u03bd\u03b7, \u03ba\u03bb\u03c0.). \u03a5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03c3\u03c4\u03b7 \u03b2\u03b9\u03b2\u03bb\u03b9\u03bf\u03b3\u03c1\u03b1\u03c6\u03af\u03b1 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\u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03ce\u03bd \u03ba\u03b1\u03b9 \u03b4\u03b9\u03ac\u03c3\u03c0\u03b1\u03c1\u03c4\u03c9\u03bd \u03b8\u03c1\u03bf\u03bc\u03b2\u03ce\u03c3\u03b5\u03c9\u03bd \u03c3\u03c4\u03bf \u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03cc \u03c3\u03cd\u03c3\u03c4\u03b7\u03bc\u03b1.\u00a0<\/span><\/p>\n<p style=\"text-align: justify;\"><b>\u00a0<\/b><\/p>\n<p style=\"text-align: justify;\"><b>\u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1<\/b><span style=\"font-weight: 400;\"><br \/><\/span><span style=\"font-weight: 400;\">\u0397 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1 \u03c4\u03bf\u03c5 APS \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03b5\u03b9 \u03bc\u03b5\u03b3\u03ac\u03bb\u03b7 \u03b5\u03c4\u03b5\u03c1\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1 \u03bc\u03b5 \u03ba\u03cd\u03c1\u03b9\u03b5\u03c2 \u03b5\u03ba\u03b4\u03b7\u03bb\u03ce\u03c3\u03b5\u03b9\u03c2 \u03c4\u03b9\u03c2 \u03b8\u03c1\u03bf\u03bc\u03b2\u03ce\u03c3\u03b5\u03b9\u03c2 \u03ae\/\u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03b1\u03c0\u03bf\u03c4\u03c5\u03c7\u03b7\u03bc\u03ad\u03bd\u03b7 \u03ad\u03ba\u03b2\u03b1\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03ba\u03cd\u03b7\u03c3\u03b7\u03c2. \u0397 \u03b5\u03bd \u03c4\u03c9 \u03b2\u03ac\u03b8\u03b5\u03b9 \u03c6\u03bb\u03b5\u03b2\u03bf\u03b8\u03c1\u03cc\u03bc\u03b2\u03c9\u03c3\u03b7 \u03c4\u03c9\u03bd \u03ba\u03ac\u03c4\u03c9 \u03ac\u03ba\u03c1\u03c9\u03bd \u03ba\u03b1\u03b9 \u03c4\u03b1 \u03b9\u03c3\u03c7\u03b1\u03b9\u03bc\u03b9\u03ba\u03ac \u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ac \u03b5\u03b3\u03ba\u03b5\u03c6\u03b1\u03bb\u03b9\u03ba\u03ac \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf\u03b9 \u03c0\u03b9\u03bf \u03c3\u03c5\u03c7\u03bd\u03ad\u03c2 \u03b5\u03ba\u03b4\u03b7\u03bb\u03ce\u03c3\u03b5\u03b9\u03c2 \u03c4\u03bf\u03c5. \u0395\u03ba\u03b4\u03b7\u03bb\u03ce\u03c3\u03b5\u03b9\u03c2 \u03cc\u03bc\u03c9\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03b1\u03c0\u03cc \u03bf\u03c0\u03bf\u03b9\u03bf\u03b4\u03ae\u03c0\u03bf\u03c4\u03b5 \u03cc\u03c1\u03b3\u03b1\u03bd\u03bf \u03ae \u03b9\u03c3\u03c4\u03cc \u03bc\u03b5 \u03c0\u03c1\u03bf\u03c3\u03b2\u03bf\u03bb\u03ae \u03c4\u03bf\u03c5 \u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03bf\u03cd \u03c4\u03bf\u03c5 \u03b4\u03b9\u03ba\u03c4\u03cd\u03bf\u03c5. \u038c\u03c7\u03b9 \u03c3\u03c0\u03ac\u03bd\u03b9\u03b1 \u03bf\u03b9 \u03b8\u03c1\u03bf\u03bc\u03b2\u03ce\u03c3\u03b5\u03b9\u03c2 \u03c5\u03c0\u03bf\u03c4\u03c1\u03bf\u03c0\u03b9\u03ac\u03b6\u03bf\u03c5\u03bd \u03ba\u03b1\u03b9 \u03c3\u03c5\u03c7\u03bd\u03ac \u03ad\u03c7\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03af\u03b4\u03b9\u03b1 \u03b5\u03bd\u03c4\u03cc\u03c0\u03b9\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03bf \u03b1\u03c1\u03c7\u03b9\u03ba\u03cc \u03b5\u03c0\u03b5\u03b9\u03c3\u03cc\u03b4\u03b9\u03bf. \u0393\u03b5\u03bd\u03b9\u03ba\u03ac \u03c4\u03b1 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03bc\u03b5 APS \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ac \u03bd\u03ad\u03b1 \u03c3\u03b5 \u03b7\u03bb\u03b9\u03ba\u03af\u03b1, \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03bf\u03c5\u03bd \u03bc\u03b7 \u03c0\u03c1\u03bf\u03ba\u03bb\u03b7\u03c4\u03ad\u03c2 \u03b8\u03c1\u03bf\u03bc\u03b2\u03ce\u03c3\u03b5\u03b9\u03c2 \u03ba\u03b1\u03b9 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03cc \u03bf\u03b9\u03ba\u03bf\u03b3\u03b5\u03bd\u03b5\u03b9\u03b1\u03ba\u03cc \u03b9\u03c3\u03c4\u03bf\u03c1\u03b9\u03ba\u03cc \u03b8\u03c1\u03bf\u03bc\u03b2\u03bf\u03c6\u03b9\u03bb\u03af\u03b1\u03c2. \u03a3\u03b5 \u03ad\u03bd\u03b1 \u03bc\u03b9\u03ba\u03c1\u03cc \u03b1\u03c1\u03b9\u03b8\u03bc\u03cc \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd (&lt;1%) \u03b1\u03bd\u03b1\u03c0\u03c4\u03cd\u03c3\u03c3\u03b5\u03c4\u03b1\u03b9 \u03c4\u03bf \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03c1\u03bf\u03c6\u03b9\u03ba\u03cc \u03b1\u03bd\u03c4\u03b9\u03c6\u03c9\u03c3\u03c6\u03bf\u03bb\u03b9\u03c0\u03b9\u03b4\u03b9\u03ba\u03cc \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf (CAPS), \u03c0\u03bf\u03c5 \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03b8\u03c1\u03bf\u03bc\u03b2\u03ce\u03c3\u03b5\u03b9\u03c2 \u03c3\u03b5 \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03ac \u03bc\u03b9\u03ba\u03c1\u03ac \u03b1\u03b3\u03b3\u03b5\u03af\u03b1 \u03ba\u03b1\u03b9 \u03bf\u03b4\u03b7\u03b3\u03b5\u03af \u03c3\u03b5 \u03c0\u03bf\u03bb\u03c5\u03bf\u03c1\u03b3\u03b1\u03bd\u03b9\u03ba\u03ae \u03b1\u03bd\u03b5\u03c0\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03bc\u03b5 \u03c5\u03c8\u03b7\u03bb\u03ae \u03b8\u03bd\u03b7\u03c4\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03c5\u03c0\u03b5\u03c1\u03b2\u03b1\u03af\u03bd\u03b5\u03b9 \u03c4\u03bf 50% \u03c0\u03b1\u03c1\u03ac \u03c4\u03b7\u03bd \u03b5\u03be\u03b5\u03b9\u03b4\u03b9\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03b7 \u03b1\u03bd\u03c4\u03b9\u03bc\u03b5\u03c4\u03ce\u03c0\u03b9\u03c3\u03b7. \u0386\u03bb\u03bb\u03b5\u03c2 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b5\u03ba\u03b4\u03b7\u03bb\u03ce\u03c3\u03b5\u03b9\u03c2 \u03c4\u03bf\u03c5 APS \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf\u03b9 \u03bc\u03b1\u03b9\u03b5\u03c5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b5\u03ba\u03b4\u03b7\u03bb\u03ce\u03c3\u03b5\u03b9\u03c2 \u03c0\u03bf\u03c5 \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03c5\u03bd \u03b1\u03bd\u03b5\u03be\u03ae\u03b3\u03b7\u03c4\u03bf \u03b8\u03ac\u03bd\u03b1\u03c4\u03bf \u03b5\u03bd\u03cc\u03c2 \u03ae \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03c9\u03bd \u03bc\u03bf\u03c1\u03c6\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ce\u03bd \u03b5\u03bc\u03b2\u03c1\u03cd\u03c9\u03bd \u03c3\u03c4\u03b7 10<\/span><span style=\"font-weight: 400;\">\u03b7<\/span><span style=\"font-weight: 400;\">\u00a0 \u03ae \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b1 \u03c4\u03b7\u03c2 \u03ba\u03c5\u03ae\u03c3\u03b5\u03c9\u03c2, \u03bf \u03c0\u03c1\u03cc\u03c9\u03c1\u03bf\u03c2 \u03c4\u03bf\u03ba\u03b5\u03c4\u03cc\u03c2 \u03b5\u03bd\u03cc\u03c2 \u03ae \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03bf\u03c4\u03ad\u03c1\u03c9\u03bd \u03bc\u03bf\u03c1\u03c6\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ce\u03bd \u03bd\u03b5\u03bf\u03b3\u03bd\u03ce\u03bd \u03c0\u03c1\u03b9\u03bd \u03c4\u03b7\u03bd 34<\/span><span style=\"font-weight: 400;\">\u03b7<\/span><span style=\"font-weight: 400;\">\u00a0 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b1 \u03c4\u03b7\u03c2 \u03ba\u03c5\u03ae\u03c3\u03b5\u03c9\u03c2 \u03bb\u03cc\u03b3\u03c9 \u03b5\u03ba\u03bb\u03b1\u03bc\u03c8\u03af\u03b1\u03c2 \u03ae \u03c3\u03bf\u03b2\u03b1\u03c1\u03ae\u03c2 \u03c0\u03c1\u03bf\u03b5\u03ba\u03bb\u03b1\u03bc\u03c8\u03af\u03b1\u03c2, \u03ba\u03b1\u03b9 3 \u03ae \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03b4\u03b9\u03b1\u03b4\u03bf\u03c7\u03b9\u03ba\u03ad\u03c2 \u03b1\u03bd\u03b5\u03be\u03ae\u03b3\u03b7\u03c4\u03b5\u03c2 \u03b1\u03c0\u03bf\u03b2\u03bf\u03bb\u03ad\u03c2 \u03c0\u03c1\u03b9\u03bd \u03c4\u03b7 10<\/span><span style=\"font-weight: 400;\">\u03b7<\/span><span style=\"font-weight: 400;\">\u00a0 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b1 \u03c4\u03b7\u03c2 \u03ba\u03c5\u03ae\u03c3\u03b5\u03c9\u03c2.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-weight: 400;\">\u0395\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2 \u03bf\u03b9 \u03bf\u03c0\u03bf\u03af\u03b5\u03c2 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03bf \u0391\u03a6\u03a3, \u03c7\u03c9\u03c1\u03af\u03c2 \u03cc\u03bc\u03c9\u03c2 \u03bd\u03b1 \u03c3\u03c5\u03bc\u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf\u03bd \u03bf\u03c1\u03b9\u03c3\u03bc\u03cc \u03c4\u03bf\u03c5, \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03ac\u03bb\u03bb\u03c9\u03bd \u03b7 \u03b4\u03b9\u03ba\u03c4\u03c5\u03c9\u03c4\u03ae \u03c0\u03b5\u03bb\u03af\u03c9\u03c3\u03b7 (Livedo reticularis), \u03b7 \u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7, \u03b7 \u03bd\u03b5\u03c6\u03c1\u03bf\u03c0\u03ac\u03b8\u03b5\u03b9\u03b1, \u03b7 \u03b1\u03c0\u03ce\u03bb\u03b5\u03b9\u03b1 \u03c4\u03b7\u03c2 \u03b1\u03ba\u03bf\u03ae\u03c2, \u03c4\u03bf ARDS, \u03b7 \u03b2\u03b1\u03bb\u03b2\u03b9\u03b4\u03bf\u03c0\u03ac\u03b8\u03b5\u03b9\u03b1 \u03ba\u03b1\u03b8\u03ce\u03c2 \u03ba\u03b1\u03b9 \u03c0\u03bf\u03b9\u03ba\u03af\u03bb\u03b5\u03c2 \u03bd\u03b5\u03c5\u03c1\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ad\u03c2 \u03b5\u03ba\u03b4\u03b7\u03bb\u03ce\u03c3\u03b5\u03b9\u03c2 \u03cc\u03c0\u03c9\u03c2 \u03c7\u03bf\u03c1\u03b5\u03af\u03b1, \u03b7\u03bc\u03b9\u03ba\u03c1\u03b1\u03bd\u03af\u03b1, \u03c0\u03b1\u03c1\u03bf\u03b4\u03b9\u03ba\u03cc \u03b9\u03c3\u03c7\u03b1\u03b9\u03bc\u03b9\u03ba\u03cc \u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03cc \u03b5\u03b3\u03ba\u03b5\u03c6\u03b1\u03bb\u03b9\u03ba\u03cc \u03b5\u03c0\u03b5\u03b9\u03c3\u03cc\u03b4\u03b9\u03bf, \u03b5\u03c0\u03b9\u03bb\u03b7\u03c8\u03af\u03b1, \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf \u03c0\u03c1\u03bf\u03c3\u03bf\u03bc\u03bf\u03b9\u03ac\u03b6\u03bf\u03bd \u03bc\u03b5 \u03c3\u03ba\u03bb\u03ae\u03c1\u03c5\u03bd\u03c3\u03b7 \u03ba\u03b1\u03c4\u03ac \u03c0\u03bb\u03ac\u03ba\u03b1\u03c2, \u03ba\u03bb\u03c0. (\u03a0\u03af\u03bd\u03b1\u03ba\u03b1\u03c2 1).<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-weight: 400;\"><\/span><\/p>\n<p style=\"text-align: justify;\">\n<p style=\"text-align: justify;\"><b>\u0394\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7<\/b><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-weight: 400;\">\u03a4\u03b1 \u03ba\u03c1\u03b9\u03c4\u03ae\u03c1\u03b9\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 APS (\u03ba\u03c1\u03b9\u03c4\u03ae\u03c1\u03b9\u03b1 \u03c4\u03bf\u03c5 \u03a3\u03af\u03b4\u03bd\u03b5\u03ca, 2006) \u03ba\u03b1\u03b8\u03b9\u03c3\u03c4\u03bf\u03cd\u03bd \u03b1\u03c0\u03b1\u03c1\u03b1\u03af\u03c4\u03b7\u03c4\u03b7 \u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1 \u03c3\u03b5 \u03bc\u03b5\u03c3\u03b1\u03af\u03b1 \u03c0\u03c1\u03bf\u03c2 \u03c5\u03c8\u03b7\u03bb\u03ac \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03b1\u03bd\u03c4\u03b9\u03c6\u03c9\u03c3\u03c6\u03bf\u03bb\u03b9\u03c0\u03b9\u03b4\u03b9\u03ba\u03ce\u03bd \u03b1\u03bd\u03c4\u03b9\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd aPL (IgM \u03ae IgG \u03b9\u03c3\u03bf\u03c4\u03cd\u03c0\u03bf\u03c5), \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03b1\u03bd\u03c4\u03b9\u03ba\u03b1\u03c1\u03b4\u03b9\u03bf\u03bb\u03b9\u03c0\u03b9\u03bd\u03b9\u03ba\u03ac \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03ae \u03b1\u03bd\u03c4\u03b9\u03c0\u03b7\u03ba\u03c4\u03b9\u03ba\u03cc \u03c4\u03bf\u03c5 \u03bb\u03cd\u03ba\u03bf\u03c5 \u03ae \u03ba\u03b1\u03b9 \u03c4\u03b1 \u03b4\u03cd\u03bf. \u0397 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1 \u03c4\u03c9\u03bd aPL \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b4\u03b9\u03b1\u03c0\u03b9\u03c3\u03c4\u03ce\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03c4\u03bf\u03c5\u03bb\u03ac\u03c7\u03b9\u03c3\u03c4\u03bf\u03bd 2 \u03c3\u03c5\u03bd\u03b5\u03c7\u03b5\u03af\u03c2 \u03bc\u03b5\u03c4\u03c1\u03ae\u03c3\u03b5\u03b9\u03c2 \u03c0\u03bf\u03c5 \u03b1\u03c0\u03ad\u03c7\u03bf\u03c5\u03bd \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03c4\u03bf\u03c5\u03c2 12 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2 \u03ad\u03c4\u03c3\u03b9 \u03ce\u03c3\u03c4\u03b5 \u03bd\u03b1 \u03b4\u03b9\u03b1\u03ba\u03c1\u03af\u03bd\u03bf\u03c5\u03bc\u03b5 \u03c4\u03b7\u03bd \u03b5\u03c0\u03af\u03bc\u03bf\u03bd\u03b7 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1 \u03c4\u03c9\u03bd \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03c3\u03c4\u03bf \u03c0\u03bb\u03ac\u03c3\u03bc\u03b1 \u03c4\u03bf\u03c5 \u03b1\u03af\u03bc\u03b1\u03c4\u03bf\u03c2 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03bf\u03b4\u03b9\u03ba\u03ae \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd \u03c4\u03af\u03c4\u03bb\u03c9\u03bd \u03c4\u03bf\u03c5\u03c2 \u03c0\u03bf\u03c5 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03bf\u03c6\u03b5\u03af\u03bb\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03bc\u03b9\u03b1 \u03bb\u03bf\u03af\u03bc\u03c9\u03be\u03b7 \u03ae \u03c3\u03c4\u03b7\u03bd \u03c7\u03c1\u03ae\u03c3\u03b7 \u03ba\u03ac\u03c0\u03bf\u03b9\u03c9\u03bd \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03c9\u03bd. \u0393\u03b5\u03bd\u03b9\u03ba\u03ac \u03c4\u03bf \u03b1\u03bd\u03c4\u03b9\u03c0\u03b7\u03ba\u03c4\u03b9\u03ba\u03cc \u03c4\u03bf\u03c5 \u03bb\u03cd\u03ba\u03bf\u03c5 LAC \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03b5\u03b9\u03b4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b3\u03b9\u03b1 APS \u03b5\u03bd\u03ce \u03c4\u03b1 \u03b1\u03bd\u03c4\u03b9\u03ba\u03b1\u03c1\u03b4\u03b9\u03bf\u03bb\u03b9\u03c0\u03b9\u03bd\u03b9\u03ba\u03ac \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03ad\u03c7\u03bf\u03c5\u03bd \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03b5\u03c5\u03b1\u03b9\u03c3\u03b8\u03b7\u03c3\u03af\u03b1. \u0397 \u03b5\u03b9\u03b4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03c9\u03bd \u03b1\u03bd\u03c4\u03b9\u03ba\u03b1\u03c1\u03b4\u03b9\u03bf\u03bb\u03b9\u03c0\u03b9\u03bd\u03b9\u03ba\u03ce\u03bd \u03b1\u03bd\u03c4\u03b9\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03ba\u03b1\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c5\u03c8\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03b7 \u03b3\u03b9\u03b1 \u03c4\u03b1 IgG \u03c3\u03b5 \u03c3\u03c7\u03ad\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03b1 IgM. \u0391\u03bd\u03b1\u03c6\u03ad\u03c1\u03b5\u03c4\u03b1\u03b9 \u03cc\u03c4\u03b9 \u03c4\u03b1 \u03c0\u03b1\u03c1\u03b1\u03c0\u03ac\u03bd\u03c9 \u03ba\u03c1\u03b9\u03c4\u03ae\u03c1\u03b9\u03b1 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b5\u03c5\u03b1\u03b9\u03c3\u03b8\u03b7\u03c3\u03af\u03b1 \u03c0\u03bf\u03c5 \u03b1\u03b3\u03b3\u03af\u03b6\u03b5\u03b9 \u03c4\u03bf 71% \u03ba\u03b1\u03b9 \u03b5\u03b9\u03b4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5 98 %. \u0397 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 APS \u03c4\u03af\u03b8\u03b5\u03c4\u03b1\u03b9 \u03cc\u03c4\u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03c4\u03bf\u03c5\u03bb\u03ac\u03c7\u03b9\u03c3\u03c4\u03bf\u03bd \u03ad\u03bd\u03b1 \u03b1\u03c0\u03cc \u03c4\u03b1 \u03c0\u03b1\u03c1\u03b1\u03ba\u03ac\u03c4\u03c9 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ac \u03ba\u03c1\u03b9\u03c4\u03ae\u03c1\u03b9\u03b1 \u03bc\u03b5 \u03ad\u03bd\u03b1 \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03cc \u03ba\u03c1\u03b9\u03c4\u03ae\u03c1\u03b9\u03bf (\u03a0\u03af\u03bd\u03b1\u03ba\u03b1\u03c2 2). \u03a3\u03cd\u03bc\u03c6\u03c9\u03bd\u03b1 \u03bc\u03b5 \u03c4\u03b1 \u03c0\u03b1\u03c1\u03b1\u03c0\u03ac\u03bd\u03c9 \u03bf\u03b9 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ae \u03b8\u03c1\u03cc\u03bc\u03b2\u03c9\u03c3\u03b7 \u03ae \u03b5\u03c0\u03b9\u03c0\u03bb\u03bf\u03ba\u03ad\u03c2 \u03ba\u03cd\u03b7\u03c3\u03b7\u03c2 (\u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03ba\u03b1\u03b8\u2019 \u03ad\u03be\u03b9\u03bd \u03b1\u03c0\u03bf\u03b2\u03bf\u03bb\u03ad\u03c2) \u03ba\u03b1\u03b9 \u03bd\u03b1 \u03b1\u03bd\u03b9\u03c7\u03bd\u03b5\u03cd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf \u03b1\u03af\u03bc\u03b1 \u03c4\u03bf\u03c5\u03c2 \u03c4\u03b1 \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03b1\u03c5\u03c4\u03ac. \u0397 \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03bf\u03c5 \u03c3\u03c5\u03bd\u03b4\u03c1\u03cc\u03bc\u03bf\u03c5 \u03c3\u03c4\u03bf \u03b3\u03b5\u03bd\u03b9\u03ba\u03cc \u03c0\u03bb\u03b7\u03b8\u03c5\u03c3\u03bc\u03cc \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03c0\u03b1\u03ba\u03c1\u03b9\u03b2\u03ce\u03c2 \u03b3\u03bd\u03c9\u03c3\u03c4\u03ae \u03ba\u03b1\u03b9 \u03c9\u03c2 \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ae \u03c0\u03b9\u03b8\u03b1\u03bd\u03ce\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c5\u03c0\u03bf\u03b4\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03bc\u03ad\u03bd\u03b7. \u0395\u03bd \u03c4\u03bf\u03cd\u03c4\u03bf\u03b9\u03c2 aCL \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03b2\u03c1\u03af\u03c3\u03ba\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf \u03b3\u03b5\u03bd\u03b9\u03ba\u03cc \u03c0\u03bb\u03b7\u03b8\u03c5\u03c3\u03bc\u03cc \u03bc\u03b5 \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 1-4,5%. \u0391\u03ba\u03cc\u03bc\u03b7 \u03b7 \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 aCL \u03b1\u03bd\u03c4\u03b9\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03c6\u03bb\u03b5\u03b2\u03b9\u03ba\u03ae \u03b8\u03c1\u03cc\u03bc\u03b2\u03c9\u03c3\u03b7 \u03ba\u03c5\u03bc\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5\u03c4\u03b1\u03be\u03cd 5-16% \u03ba\u03b1\u03b9 \u03c3&#8217; \u03b1\u03c5\u03c4\u03bf\u03cd\u03c2 \u03bc\u03b5 \u03b1\u03c1\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ae \u03b8\u03c1\u03cc\u03bc\u03b2\u03c9\u03c3\u03b7 \u03bc\u03b5\u03c4\u03b1\u03be\u03cd 5-46%. \u03a4\u03bf APS \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf \u03b1\u03c0\u03b1\u03bd\u03c4\u03ac\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc 0,3% \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03c4\u03bf\u03c5 \u03b5\u03b3\u03ba\u03cd\u03bc\u03bf\u03bd\u03b1 \u03c0\u03bb\u03b7\u03b8\u03c5\u03c3\u03bc\u03bf\u03cd.\u00a0 \u039f\u03b9 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03bf\u03b9 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 (98%) \u03bc\u03b5 APS \u03b1\u03bd\u03ae\u03ba\u03bf\u03c5\u03bd \u03c3\u03c4\u03b7 \u03bb\u03b5\u03c5\u03ba\u03ae \u03c6\u03c5\u03bb\u03ae, \u03b5\u03bd\u03ce \u03c4\u03bf \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc \u03c3\u03c4\u03b7 \u03bc\u03b1\u03cd\u03c1\u03b7 \u03c6\u03c5\u03bb\u03ae \u03ba\u03c5\u03bc\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf 0,5%. \u0397 \u03bc\u03ad\u03c3\u03b7 \u03b7\u03bb\u03b9\u03ba\u03af\u03b1 \u03ad\u03bd\u03b1\u03c1\u03be\u03b7\u03c2 \u03c4\u03c9\u03bd \u03c3\u03c5\u03bc\u03c0\u03c4\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5 \u03c4\u03b1 34 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1, \u03bc\u03b5 \u03c4\u03bf 85% \u03c4\u03c9\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03c0\u03bf\u03c5 \u03b4\u03b9\u03b1\u03b3\u03bd\u03ce\u03c3\u03c4\u03b7\u03ba\u03b1\u03bd \u03bd\u03b1 \u03ba\u03c5\u03bc\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03c4\u03c9\u03bd \u03b7\u03bb\u03b9\u03ba\u03b9\u03ce\u03bd 15 \u03ba\u03b1\u03b9 50 \u03b5\u03c4\u03ce\u03bd.\u00a0 \u0397 \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7 \u03b1\u03bd\u03c4\u03b9\u03c6\u03c9\u03c3\u03c6\u03bf\u03bb\u03b9\u03c0\u03b9\u03b4\u03b9\u03ba\u03ce\u03bd \u03b1\u03bd\u03c4\u03b9\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03c5\u03c7\u03bd\u03ae \u03c3\u03c4\u03b1 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7\u03c2 \u03b7\u03bb\u03b9\u03ba\u03af\u03b1\u03c2. \u03a3\u03c4\u03b7\u03bd \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 A. Duarte-Garcia et al (2017) \u03b7 \u03b5\u03c0\u03af\u03c0\u03c4\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 APS \u03b5\u03af\u03bd\u03b1\u03b9 2\/100.000 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03b7\u03bb\u03b9\u03ba\u03af\u03b1\u03c2 \u03ac\u03bd\u03c9 \u03c4\u03c9\u03bd 18 \u03b5\u03c4\u03ce\u03bd. \u0397 \u03bc\u03ad\u03b3\u03b9\u03c3\u03c4\u03b7 \u03b5\u03c0\u03af\u03c0\u03c4\u03c9\u03c3\u03b7 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03ae\u03b8\u03b7\u03ba\u03b5 \u03c3\u03b5 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03ac\u03bd\u03c9 \u03c4\u03c9\u03bd 75 \u03b5\u03c4\u03ce\u03bd, \u03b5\u03bd\u03ce \u03c3\u03c4\u03b7\u03bd \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b7 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03b4\u03b5\u03bd \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03ae\u03b8\u03b7\u03ba\u03b5 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03ac \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03c4\u03c9\u03bd \u03b4\u03cd\u03bf \u03c6\u03cd\u03bb\u03c9\u03bd.<\/span><\/p>\n<p style=\"text-align: justify;\"><b>\u03a0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03a6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 APS<\/b><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-weight: 400;\">\u03a4\u03b1 \u03b1\u03bd\u03c4\u03b9\u03c6\u03c9\u03c3\u03c6\u03bf\u03bb\u03b9\u03c0\u03b9\u03b4\u03b9\u03ba\u03ac \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b9\u03b1 \u03b5\u03c4\u03b5\u03c1\u03bf\u03b3\u03b5\u03bd\u03ae\u03c2 \u03bf\u03bc\u03ac\u03b4\u03b1 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03b4\u03b9\u03cc\u03c4\u03b9 \u03c3\u03c4\u03c1\u03ad\u03c6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b5\u03bd\u03b1\u03bd\u03c4\u03af\u03bf\u03bd \u03bc\u03b5\u03b3\u03ac\u03bb\u03b7\u03c2 \u03c0\u03bf\u03b9\u03ba\u03b9\u03bb\u03af\u03b1\u03c2 \u03b1\u03bd\u03c4\u03b9\u03b3\u03bf\u03bd\u03b9\u03ba\u03ce\u03bd \u03c3\u03c4\u03cc\u03c7\u03c9\u03bd.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-weight: 400;\">\u0391\u03bd\u03c4\u03b9\u03b3\u03bf\u03bd\u03b9\u03ba\u03bf\u03af \u03c3\u03c4\u03cc\u03c7\u03bf\u03b9 \u03c4\u03bf\u03c5\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03b7 \u03b22-\u03b3\u03bb\u03c5\u03ba\u03bf\u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7 \u0399 (\u03b1\u03bd\u03c4\u03b9 \u03b22-GPI \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1), \u03b7 \u03c0\u03c1\u03bf\u03b8\u03c1\u03bf\u03bc\u03b2\u03af\u03bd\u03b7 (\u03b1\u03bd\u03c4\u03b9-\u03c0\u03c1\u03bf\u03b8\u03c1\u03bf\u03bc\u03b2\u03b9\u03bd\u03b9\u03ba\u03ac \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1), \u03bf \u03b9\u03c3\u03c4\u03b9\u03ba\u03cc\u03c2 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03ae\u03c2 \u03c0\u03bb\u03b1\u03c3\u03bc\u03b9\u03bd\u03bf\u03b3\u03cc\u03bd\u03bf\u03c5 t-PA (\u03b1\u03bd\u03c4\u03b9 t-PA \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1), \u03bf \u03b5\u03bd\u03b4\u03bf\u03b8\u03b7\u03bb\u03b9\u03b1\u03ba\u03cc\u03c2 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1\u03c2 \u03c4\u03b7\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7\u03c2 C EPCR (\u03b1\u03bd\u03c4\u03b9 EPCR \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1), \u03b7 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7 C, \u03b7 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7 S \u03bf \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1\u03c2 \u03a7\u0399\u0399, \u03b7 \u03b1\u03bd\u03bd\u03b5\u03be\u03af\u03bd\u03b7 V, \u03c4\u03bf \u03c5\u03c8\u03b7\u03bb\u03bf\u03cd \u03bc\u03bf\u03c1\u03b9\u03b1\u03ba\u03bf\u03cd \u03b2\u03ac\u03c1\u03bf\u03c5\u03c2 \u03ba\u03b9\u03bd\u03b9\u03bd\u03bf\u03b3\u03cc\u03bd\u03bf, \u03c4\u03bf \u03c0\u03bb\u03b1\u03c3\u03bc\u03b9\u03bd\u03bf\u03b3\u03cc\u03bd\u03bf, \u03c6\u03c9\u03c3\u03c6\u03bf\u03bb\u03b9\u03c0\u03ac\u03c3\u03b5\u03c2, \u03bf \u03c0\u03b1\u03c1\u03ac\u03b3\u03c9\u03bd \u03c3\u03c5\u03bc\u03c0\u03bb\u03b7\u03c1\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2 H \u03ba\u03b1\u03b9 \u03ac\u03bb\u03bb\u03bf\u03b9. \u039f\u03b9 \u03c0\u03b1\u03c1\u03b1\u03c0\u03ac\u03bd\u03c9 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b5\u03c2 \u03c3\u03c4\u03cc\u03c7\u03bf\u03b9 \u03c0\u03b5\u03c1\u03b9\u03ad\u03c7\u03bf\u03c5\u03bd \u03c3\u03c4\u03b7 \u03b4\u03bf\u03bc\u03ae \u03c4\u03bf\u03c5 \u03bc\u03bf\u03c1\u03af\u03bf\u03c5 \u03c4\u03bf\u03c5\u03c2 \u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03ad\u03c2 &#8211; \u03c4\u03bc\u03ae\u03bc\u03b1\u03c4\u03b1 \u03c0\u03bf\u03c5 \u03b4\u03b5\u03c3\u03bc\u03b5\u03cd\u03bf\u03c5\u03bd \u03c6\u03c9\u03c3\u03c6\u03bf\u03bb\u03b9\u03c0\u03af\u03b4\u03b9\u03b1 (phospholipid binding domains) \u03cc\u03c0\u03c9\u03c2 \u03ba\u03b1\u03c1\u03b4\u03b9\u03bf\u03bb\u03b9\u03c0\u03af\u03bd\u03b7, \u03c6\u03c9\u03c3\u03c6\u03b1\u03c4\u03b9\u03b4\u03c5\u03bb\u03bf\u03c3\u03b5\u03c1\u03af\u03bd\u03b7, \u03c6\u03c9\u03c3\u03c6\u03b1\u03c4\u03b9\u03b4\u03c5\u03bb\u03bf\u03b1\u03b9\u03b8\u03b1\u03bd\u03bf\u03bb\u03b1\u03bc\u03af\u03bd\u03b7, \u03c6\u03c9\u03c3\u03c6\u03b1\u03c4\u03b9\u03b4\u03c5\u03bb\u03bf\u03ca\u03bd\u03bf\u03c3\u03b9\u03c4\u03cc\u03bb\u03b7, \u03c6\u03c9\u03c3\u03c6\u03b1\u03c4\u03b9\u03b4\u03b9\u03ba\u03cc \u03bf\u03be\u03cd \u03ba\u03b1\u03b9 \u03ac\u03bb\u03bb\u03b1. \u0395\u03bd\u03b1\u03bd\u03c4\u03af\u03bf\u03bd \u03b1\u03c5\u03c4\u03ce\u03bd \u03c4\u03c9\u03bd \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03ce\u03bd \u03c0\u03bf\u03c5 \u03b4\u03b5\u03c3\u03bc\u03b5\u03cd\u03bf\u03c5\u03bd \u03c6\u03c9\u03c3\u03c6\u03bf\u03bb\u03b9\u03c0\u03af\u03b4\u03b9\u03b1 \u03ba\u03b1\u03c4\u03b5\u03c5\u03b8\u03cd\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c4\u03b1 \u03b1\u03bd\u03c4\u03b9\u03c6\u03c9\u03c3\u03c6\u03bf\u03bb\u03b9\u03c0\u03b9\u03b4\u03b9\u03ba\u03ac \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-weight: 400;\">\u0397 \u03b22-\u03b3\u03bb\u03c5\u03ba\u03bf\u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7 \u0399 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03b1\u03c1\u03bf\u03cd\u03c3\u03b1 \u03c3\u03c4\u03bf \u03c0\u03bb\u03ac\u03c3\u03bc\u03b1 \u03c3\u03b5 \u03c3\u03c5\u03b3\u03ba\u03b5\u03bd\u03c4\u03c1\u03ce\u03c3\u03b5\u03b9\u03c2 \u03c0\u03bf\u03c5 \u03ba\u03c5\u03bc\u03b1\u03af\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc 10 \u03ad\u03c9\u03c2 300 \u03bcg\/ml (0.25 \u03bc\u03b5 5.0 \u03bcM) \u03ba\u03b1\u03b9 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03c6\u03c5\u03c3\u03b9\u03ba\u03cc \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ad\u03b1 \u03c4\u03b7\u03c2 \u03c0\u03ae\u03be\u03b5\u03c9\u03c2. \u03a3\u03c5\u03bd\u03c4\u03af\u03b8\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b1 \u03b5\u03bd\u03b4\u03bf\u03b8\u03b7\u03bb\u03b9\u03b1\u03ba\u03ac \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1, \u03c3\u03c4\u03bf\u03bd \u03c0\u03bb\u03b1\u03ba\u03bf\u03cd\u03bd\u03c4\u03b1, \u03c3\u03c4\u03bf \u03ba\u03b5\u03bd\u03c4\u03c1\u03b9\u03ba\u03cc \u03bd\u03b5\u03c5\u03c1\u03b9\u03ba\u03cc \u03c3\u03cd\u03c3\u03c4\u03b7\u03bc\u03b1 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b1 \u03b7\u03c0\u03b1\u03c4\u03bf\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03b1\u03bb\u03bb\u03ac \u03b7 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03c0\u03b7\u03b3\u03ae \u03c3\u03cd\u03bd\u03b8\u03b5\u03c3\u03ae\u03c2 \u03c4\u03b7\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03bf \u03ae\u03c0\u03b1\u03c1. \u0397 \u03c4\u03c1\u03b9\u03c3\u03b4\u03b9\u03ac\u03c3\u03c4\u03b1\u03c4\u03b7 \u03b4\u03bf\u03bc\u03ae \u03c4\u03bf\u03c5 \u03bc\u03bf\u03c1\u03af\u03bf\u03c5 \u03c4\u03b7\u03c2 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc 5 \u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03ad\u03c2. \u0397 \u03b22-GPI \u03c3\u03c5\u03bd\u03b4\u03ad\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03bc\u03b9\u03b1 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae \u03bc\u03b5\u03bc\u03b2\u03c1\u03ac\u03bd\u03b7 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03ae V, \u03bf\u03b9 \u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03ad\u03c2 III \u03ba\u03b1\u03b9 IV \u03b5\u03af\u03bd\u03b1\u03b9 \u03b3\u03bb\u03c5\u03ba\u03bf\u03b6\u03c5\u03bb\u03b9\u03c9\u03bc\u03ad\u03bd\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03ad\u03c4\u03c3\u03b9 \u03c0\u03c1\u03bf\u03c3\u03c4\u03b1\u03c4\u03b5\u03c5\u03bc\u03ad\u03bd\u03b5\u03c2 \u03b1\u03c0\u03cc \u03b1\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03bc\u03b5 \u03ac\u03bb\u03bb\u03b5\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b5\u03c2, \u03b5\u03bd\u03ce \u03bf\u03b9 \u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03ad\u03c2 I \u03ba\u03b1\u03b9 II \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03ba\u03c4\u03b5\u03b8\u03b5\u03b9\u03bc\u03ad\u03bd\u03b5\u03c2 \u03bc\u03b1\u03ba\u03c1\u03b9\u03ac \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae \u03bc\u03b5\u03bc\u03b2\u03c1\u03ac\u03bd\u03b7 \u03ba\u03b1\u03b9 \u03c0\u03b1\u03c1\u03ad\u03c7\u03bf\u03c5\u03bd \u03b8\u03ad\u03c3\u03b5\u03b9\u03c2 \u03c0\u03c1\u03cc\u03c3\u03b4\u03b5\u03c3\u03b7\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b1 \u03b1\u03bd\u03c4\u03b9\u03c6\u03c9\u03c3\u03c6\u03bf\u03bb\u03b9\u03c0\u03b9\u03b4\u03b9\u03ba\u03ac \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 aPL.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-weight: 400;\">\u03a4\u03b1 \u03b1\u03bd\u03c4\u03b9\u03c6\u03c9\u03c3\u03c6\u03bf\u03bb\u03b9\u03c0\u03b9\u03b4\u03b9\u03ba\u03ac \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 aPL \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03bf\u03cd\u03bd \u03bc\u03b9\u03b1 \u03b5\u03c4\u03b5\u03c1\u03bf\u03b3\u03b5\u03bd\u03ae \u03bf\u03bc\u03ac\u03b4\u03b1 \u03b1\u03c5\u03c4\u03bf\u03b1\u03bd\u03c4\u03b9\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd, \u03ad\u03c7\u03bf\u03c5\u03bd \u03cc\u03bc\u03c9\u03c2 \u03c9\u03c2 \u03ba\u03bf\u03b9\u03bd\u03cc \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03cc \u03ad\u03bd\u03b1 \u03c0\u03b1\u03c1\u03ac\u03b4\u03bf\u03be\u03bf \u03b3\u03b5\u03b3\u03bf\u03bd\u03cc\u03c2. In vitro \u03b1\u03bd\u03b1\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03c5\u03bd \u03c4\u03bf \u03c3\u03c7\u03b7\u03bc\u03b1\u03c4\u03b9\u03c3\u03bc\u03cc \u03c4\u03bf\u03c5 \u03c3\u03c5\u03bc\u03c0\u03bb\u03ad\u03b3\u03bc\u03b1\u03c4\u03bf\u03c2 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03c0\u03c1\u03bf\u03b8\u03c1\u03bf\u03bc\u03b2\u03af\u03bd\u03b7\u03c2 (\u03c0\u03c1\u03bf\u03c3\u03ba\u03bf\u03bb\u03bb\u03ce\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03c6\u03c9\u03c3\u03c6\u03bf\u03bb\u03b9\u03c0\u03b9\u03b4\u03b9\u03ba\u03ae \u03b5\u03c0\u03b9\u03c6\u03ac\u03bd\u03b5\u03b9\u03b1 \u03c4\u03bf\u03c5 \u03c3\u03c5\u03bc\u03c0\u03bb\u03ad\u03b3\u03bc\u03b1\u03c4\u03bf\u03c2), \u03b5\u03c0\u03b9\u03b2\u03c1\u03b1\u03b4\u03cd\u03bd\u03bf\u03c5\u03bd \u03c4\u03bf \u03c3\u03c7\u03b7\u03bc\u03b1\u03c4\u03b9\u03c3\u03bc\u03cc \u03c4\u03b7\u03c2 \u03b8\u03c1\u03bf\u03bc\u03b2\u03af\u03bd\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03ac\u03c1\u03b1 \u03b5\u03c0\u03b9\u03bc\u03b7\u03ba\u03cd\u03bd\u03bf\u03c5\u03bd \u03c4\u03bf \u03c7\u03c1\u03cc\u03bd\u03bf \u03c4\u03c9\u03bd \u03b4\u03bf\u03ba\u03b9\u03bc\u03b1\u03c3\u03b9\u03ce\u03bd \u03c0\u03ae\u03be\u03b5\u03c9\u03c2. In vivo \u03cc\u03bc\u03c9\u03c2 \u03b7 \u03b4\u03c1\u03ac\u03c3\u03b7 \u03c4\u03bf\u03c5\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ae \u03ba\u03b1\u03b9 \u03b4\u03b7\u03bc\u03b9\u03bf\u03c5\u03c1\u03b3\u03bf\u03cd\u03bd \u03c3\u03c5\u03bd\u03b8\u03ae\u03ba\u03b5\u03c2 \u03c5\u03c0\u03b5\u03c1\u03c0\u03b7\u03ba\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03c0\u03bf\u03c5 \u03bf\u03b4\u03b7\u03b3\u03bf\u03cd\u03bd \u03c3\u03b5 \u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ad\u03c2 \u03b8\u03c1\u03bf\u03bc\u03b2\u03ce\u03c3\u03b5\u03b9\u03c2.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-weight: 400;\">\u039f\u03b9 \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03af \u03c0\u03bf\u03c5 \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03ad\u03c7\u03bf\u03c5\u03bd \u03c3\u03c4\u03b7\u03bd \u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ae \u03b8\u03c1\u03cc\u03bc\u03b2\u03c9\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c4\u03b9\u03c2 \u03b1\u03c5\u03c4\u03cc\u03bc\u03b1\u03c4\u03b5\u03c2 \u03b1\u03c0\u03bf\u03b2\u03bf\u03bb\u03ad\u03c2 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03b1\u03bd\u03c4\u03b9\u03c6\u03c9\u03c3\u03c6\u03bf\u03bb\u03b9\u03c0\u03b9\u03b4\u03b9\u03ba\u03cc \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf \u03b4\u03b5\u03bd \u03ad\u03c7\u03bf\u03c5\u03bd \u03b1\u03ba\u03cc\u03bc\u03b7 \u03c0\u03bb\u03ae\u03c1\u03c9\u03c2 \u03b4\u03b9\u03b5\u03c5\u03ba\u03c1\u03b9\u03bd\u03b9\u03c3\u03c4\u03b5\u03af, \u03c9\u03c3\u03c4\u03cc\u03c3\u03bf \u03c0\u03c1\u03bf\u03c4\u03b5\u03af\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9\u00a0\u03b4\u03b9\u03ac\u03c6\u03bf\u03c1\u03bf\u03b9 \u03c0\u03b1\u03b8\u03bf\u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03bf\u03af \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03af\u00a0.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-weight: 400;\">\u0395\u03af\u03bd\u03b1\u03b9 \u03b3\u03bd\u03c9\u03c3\u03c4\u03cc \u03cc\u03c4\u03b9 \u03c4\u03b1 aPL \u03b5\u03c0\u03b5\u03bc\u03b2\u03b1\u03af\u03bd\u03bf\u03c5\u03bd \u03c3\u03c4\u03bf\u03bd \u03ba\u03b1\u03c4\u03b1\u03c1\u03c1\u03ac\u03ba\u03c4\u03b7 \u03c4\u03b7\u03c2 \u03c0\u03ae\u03be\u03b5\u03c9\u03c2 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03c4\u03b7\u03c2 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03b7\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7\u03c2 C \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 \u03b1\u03bd\u03c4\u03b9\u03b8\u03c1\u03bf\u03bc\u03b2\u03af\u03bd\u03b7\u03c2 \u0399\u0399\u0399, \u03bc\u03b5 \u03c4\u03b7\u03bd \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03c4\u03b7\u03c2 \u03b9\u03bd\u03c9\u03b4\u03cc\u03bb\u03c5\u03c3\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b4\u03c1\u03ac\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 \u03b9\u03c3\u03c4\u03b9\u03ba\u03bf\u03cd \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1 TF \u03bf \u03bf\u03c0\u03bf\u03af\u03bf\u03c2 \u03be\u03b5\u03ba\u03b9\u03bd\u03ac \u03c4\u03b7\u03bd \u03b5\u03be\u03c9\u03b3\u03b5\u03bd\u03ae \u03bf\u03b4\u03cc \u03c0\u03ae\u03be\u03b5\u03c9\u03c2. \u0395\u03c0\u03af\u03c3\u03b7\u03c2 \u03b7 \u03b22-\u03b3\u03bb\u03c5\u03ba\u03bf\u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7 \u0399 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1\u03c2 \u03c6\u03c5\u03c3\u03b9\u03ba\u03cc\u03c2 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ad\u03b1\u03c2 \u03c0\u03ae\u03be\u03b5\u03c9\u03c2 (\u03c3\u03c5\u03bd\u03b4\u03ad\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03b1 \u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03ac \u03c6\u03bf\u03c1\u03c4\u03b9\u03c3\u03bc\u03ad\u03bd\u03b1 \u03c6\u03c9\u03c3\u03c6\u03bf\u03bb\u03b9\u03c0\u03af\u03b4\u03b9\u03b1 \u03c4\u03b7\u03c2 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae\u03c2 \u03bc\u03b5\u03bc\u03b2\u03c1\u03ac\u03bd\u03b7\u03c2 \u03b5\u03bc\u03c0\u03bf\u03b4\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7 \u03c3\u03cd\u03bd\u03b4\u03b5\u03c3\u03b7 \u03c0\u03b1\u03c1\u03b1\u03b3\u03cc\u03bd\u03c4\u03c9\u03bd \u03c0\u03ae\u03be\u03b5\u03c9\u03c2 \u03ba\u03b1\u03b9 \u03b1\u03bd\u03b1\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03bf\u03bd \u03ba\u03b1\u03c4\u03b1\u03c1\u03c1\u03ac\u03ba\u03c4\u03b7 \u03c4\u03b7\u03c2 \u03c0\u03ae\u03be\u03b5\u03c9\u03c2 ) \u03ba\u03b1\u03b9 \u03b5\u03c0\u03bf\u03bc\u03ad\u03bd\u03c9\u03c2 \u03c4\u03b1 aPL \u03c0\u03bf\u03c5 \u03c3\u03c4\u03c1\u03ad\u03c6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b5\u03bd\u03b1\u03bd\u03c4\u03af\u03bf\u03bd \u03c4\u03b7\u03c2 \u03c0\u03b1\u03c1\u03b5\u03bc\u03c0\u03bf\u03b4\u03af\u03b6\u03bf\u03c5\u03bd \u03c4\u03bf\u03bd \u03c1\u03cc\u03bb\u03bf \u03c4\u03b7\u03c2 \u03b1\u03c5\u03c4\u03cc\u03bd. \u0386\u03bb\u03bb\u03b5\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03c1\u03cd\u03b8\u03bc\u03b9\u03c3\u03b7 \u03c4\u03c9\u03bd \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03ce\u03bd \u03c0\u03ae\u03be\u03b5\u03c9\u03c2, \u03cc\u03c0\u03c9\u03c2 \u03b7 \u03c0\u03c1\u03bf\u03b8\u03c1\u03bf\u03bc\u03b2\u03af\u03bd\u03b7, \u03bf \u03c0\u03b1\u03c1\u03ac\u03b3\u03c9\u03bd XII, \u03b7 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7 S \u03ba\u03b1\u03b9 \u03b7 \u03b1\u03bd\u03bd\u03b5\u03be\u03af\u03bd\u03b7 V, \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03bf\u03cd\u03bd \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03c3\u03c4\u03cc\u03c7\u03bf \u03c4\u03c9\u03bd aPL.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-weight: 400;\">H \u03b1\u03bd\u03bd\u03b5\u03be\u03af\u03bd\u03b7 V \u03c3\u03c7\u03b7\u03bc\u03b1\u03c4\u03af\u03b6\u03b5\u03b9 \u03c3\u03c5\u03bc\u03c0\u03bb\u03ad\u03b3\u03bc\u03b1\u03c4\u03b1 \u03bc\u03b5 \u03c4\u03b1 \u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03ac \u03c6\u03bf\u03c1\u03c4\u03b9\u03c3\u03bc\u03ad\u03bd\u03b1 \u03c6\u03c9\u03c3\u03c6\u03bf\u03bb\u03b9\u03c0\u03af\u03b4\u03b9\u03b1 \u03c4\u03b7\u03c2 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae\u03c2 \u03bc\u03b5\u03bc\u03b2\u03c1\u03ac\u03bd\u03b7\u03c2. \u0391\u03c5\u03c4\u03cc \u03ad\u03c7\u03b5\u03b9 \u03c3\u03b1\u03bd \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03bd\u03b1 \u03bc\u03c0\u03bb\u03bf\u03ba\u03ac\u03c1\u03b5\u03c4\u03b1\u03b9 \u03b7 \u03c3\u03cd\u03bd\u03b4\u03b5\u03c3\u03b7 \u03bc\u03b5 \u03c3\u03c5\u03bc\u03c0\u03bb\u03ad\u03b3\u03bc\u03b1\u03c4\u03b1 \u03c0\u03b1\u03c1\u03b1\u03b3\u03cc\u03bd\u03c4\u03c9\u03bd \u03c0\u03ae\u03be\u03b5\u03c9\u03c2 \u03ba\u03b1\u03b9 \u03b1\u03bd\u03b1\u03c3\u03c4\u03ad\u03bb\u03bb\u03b5\u03c4\u03b1\u03b9 \u03ad\u03c4\u03c3\u03b9 \u03b7 \u03b4\u03b9\u03b1\u03b4\u03b9\u03ba\u03b1\u03c3\u03af\u03b1 \u03c0\u03ae\u03be\u03b5\u03c9\u03c2. \u03a4\u03b1 \u03b1\u03bd\u03c4\u03b9\u03c6\u03c9\u03c3\u03c6\u03bf\u03bb\u03b9\u03c0\u03b9\u03b4\u03b9\u03ba\u03ac \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7\u03c2 \u03b1\u03bd\u03bd\u03b5\u03be\u03af\u03bd\u03b7\u03c2 V \u03c0\u03b1\u03c1\u03b5\u03bc\u03c0\u03bf\u03b4\u03af\u03b6\u03bf\u03c5\u03bd \u03c4\u03b7 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03c4\u03b7\u03c2 \u03b1\u03c5\u03c4\u03ae, \u03bc\u03b5 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c0\u03bf\u03bb\u03bb\u03ac \u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03ac \u03c6\u03bf\u03c1\u03c4\u03b9\u03c3\u03bc\u03ad\u03bd\u03b1 \u03c6\u03c9\u03c3\u03c6\u03bf\u03bb\u03b9\u03c0\u03af\u03b4\u03b9\u03b1 \u03bd\u03b1 \u03bc\u03ad\u03bd\u03bf\u03c5\u03bd \u03b5\u03bb\u03b5\u03cd\u03b8\u03b5\u03c1\u03b1 \u03ba\u03b1\u03b9 \u03bd\u03b1 \u03c3\u03c7\u03b7\u03bc\u03b1\u03c4\u03af\u03b6\u03bf\u03c5\u03bd \u03c3\u03c5\u03bc\u03c0\u03bb\u03ad\u03b3\u03bc\u03b1\u03c4\u03b1 \u03bc\u03b5 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b5\u03c2 \u03c0\u03ae\u03be\u03b5\u03c9\u03c2.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-weight: 400;\">\u03a4\u03bf \u03c3\u03cd\u03bc\u03c0\u03bb\u03b5\u03b3\u03bc\u03b1 \u03b22-GPI &#8211; \u03b1\u03bd\u03c4\u03b9 \u03b22-GPI \u03c0\u03c1\u03bf\u03c3\u03b4\u03ad\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 \u03c3\u03c5\u03b3\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1 \u03c3\u03c4\u03b7\u03bd \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae \u03b5\u03c0\u03b9\u03c6\u03ac\u03bd\u03b5\u03b9\u03b1 \u03c4\u03c9\u03bd \u03b5\u03bd\u03b4\u03bf\u03b8\u03b7\u03bb\u03b9\u03b1\u03ba\u03ce\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03ba\u03b1\u03b9 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03b5\u03af \u03c4\u03b7\u03bd \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03ae \u03c4\u03bf\u03c5\u03c2\u00a0(\u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd \u03bc\u03bf\u03c1\u03af\u03c9\u03bd \u03c0\u03c1\u03bf\u03c3\u03ba\u03cc\u03bb\u03bb\u03b7\u03c3\u03b7\u03c2 \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03c6\u03ac\u03bd\u03b5\u03b9\u03b1 \u03c4\u03bf\u03c5\u03c2 \u03ba\u03b1\u03b9 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 \u03ad\u03ba\u03ba\u03c1\u03b9\u03c3\u03b7 \u03b9\u03bd\u03c4\u03b5\u03c1\u03bb\u03b5\u03c5\u03ba\u03af\u03bd\u03b7\u03c2-6 \u03ba\u03b1\u03b9 \u03c0\u03c1\u03bf\u03c3\u03c4\u03b1\u03b3\u03bb\u03b1\u03bd\u03b4\u03b9\u03bd\u03ce\u03bd), \u03b3\u03b5\u03b3\u03bf\u03bd\u03cc\u03c2 \u03c0\u03bf\u03c5 \u03c0\u03c1\u03bf\u03ac\u03b3\u03b5\u03b9 \u03c4\u03b7\u03bd \u03c0\u03ae\u03be\u03b7. \u0395\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd\u00a0\u03c4\u03b1 aPL \u03c0\u03c1\u03bf\u03ac\u03b3\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c3\u03c5\u03b3\u03ba\u03cc\u03bb\u03bb\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b1\u03b9\u03bc\u03bf\u03c0\u03b5\u03c4\u03b1\u03bb\u03af\u03c9\u03bd\u00a0\u03ba\u03b1\u03b9 \u03c4\u03bf \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc \u03b3\u03ad\u03bd\u03b5\u03c3\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03c7\u03b7\u03bc\u03b1\u03c4\u03b9\u03c3\u03bc\u03bf\u03cd \u03c4\u03c9\u03bd \u03b8\u03c1\u03cc\u03bc\u03b2\u03c9\u03bd.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-weight: 400;\">\u03a4\u03b1 aPL \u03c3\u03c4\u03c1\u03ad\u03c6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03b5\u03bd\u03b1\u03bd\u03c4\u03af\u03bf\u03bd \u03bc\u03b9\u03b1\u03c2 \u03ac\u03bb\u03bb\u03b7\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7\u03c2 \u03c0\u03bf\u03c5 \u03b4\u03b5\u03c3\u03bc\u03b5\u03cd\u03b5\u03b9 \u03c6\u03c9\u03c3\u03c6\u03bf\u03bb\u03b9\u03c0\u03af\u03b4\u03b9\u03b1, \u03c4\u03bf\u03c5 \u03b5\u03bd\u03b4\u03bf\u03b8\u03b7\u03bb\u03b9\u03b1\u03ba\u03bf\u03cd \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 \u03c4\u03b7\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7\u03c2 C (EPCR). \u039f EPCR \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b9\u03b1 \u03b3\u03bb\u03c5\u03ba\u03bf\u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7 \u03c4\u03b7\u03c2 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae\u03c2 \u03bc\u03b5\u03bc\u03b2\u03c1\u03ac\u03bd\u03b7\u03c2 \u03c4\u03c9\u03bd \u03b5\u03bd\u03b4\u03bf\u03b8\u03b7\u03bb\u03b9\u03b1\u03ba\u03ce\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03c3\u03c4\u03b5\u03bd\u03ac \u03c3\u03c5\u03bd\u03b4\u03b5\u03b4\u03b5\u03bc\u03ad\u03bd\u03b7 \u03bc\u03b5 \u03c6\u03c9\u03c3\u03c6\u03bf\u03bb\u03b9\u03c0\u03af\u03b4\u03b9\u03b1 \u03ba\u03b1\u03b9 \u03c5\u03c0\u03bf\u03b4\u03ad\u03c7\u03b5\u03c4\u03b1\u03b9 \u03c4\u03b7\u03bd \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7 C \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03b7 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7 C, \u03ad\u03c7\u03bf\u03bd\u03c4\u03b1\u03c2 \u03ad\u03c4\u03c3\u03b9 \u03b1\u03bd\u03c4\u03b9\u03c0\u03b7\u03ba\u03c4\u03b9\u03ba\u03ae \u03b4\u03c1\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1. \u039a\u03c5\u03c1\u03af\u03c9\u03c2 \u03b5\u03ba\u03c6\u03c1\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03bc\u03b5\u03b3\u03ac\u03bb\u03b1 \u03b1\u03b3\u03b3\u03b5\u03af\u03b1 \u03ba\u03b1\u03b9 \u03b4\u03b7 \u03c3\u03b5 \u03b1\u03c1\u03c4\u03b7\u03c1\u03af\u03b5\u03c2 \u03b1\u03bb\u03bb\u03ac \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03c3\u03c5\u03b3\u03ba\u03c5\u03c4\u03b9\u03bf\u03c4\u03c1\u03bf\u03c6\u03bf\u03b2\u03bb\u03ac\u03c3\u03c4\u03b7. \u03a0\u03c1\u03cc\u03c3\u03c6\u03b1\u03c4\u03b5\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03c5\u03c0\u03bf\u03c3\u03c4\u03b7\u03c1\u03af\u03b6\u03bf\u03c5\u03bd \u03cc\u03c4\u03b9 \u03bf EPCR \u03ad\u03c7\u03b5\u03b9 \u03c1\u03cc\u03bb\u03bf \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b4\u03b9\u03b1\u03c4\u03ae\u03c1\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03ba\u03cd\u03b7\u03c3\u03b7\u03c2, \u03b1\u03c6\u03bf\u03cd \u03b7 \u03b1\u03c0\u03bf\u03c5\u03c3\u03af\u03b1 \u03c4\u03bf\u03c5 \u2013 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03c1\u03bf\u03c6\u03ae \u03c4\u03bf\u03c5 \u03c3\u03b5 \u03c0\u03bf\u03bd\u03c4\u03af\u03ba\u03b9\u03b1 \u03b5\u03af\u03c7\u03b5 \u03c9\u03c2 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03b8\u03c1\u03cc\u03bc\u03b2\u03c9\u03c3\u03b7 \u03c3\u03c4\u03bf\u03bd \u03c0\u03bb\u03b1\u03ba\u03bf\u03cd\u03bd\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03c0\u03c1\u03ce\u03b9\u03bc\u03bf \u03b5\u03bd\u03b4\u03bf\u03bc\u03ae\u03c4\u03c1\u03b9\u03bf \u03b8\u03ac\u03bd\u03b1\u03c4\u03bf. \u038c\u03bb\u03b1 \u03c4\u03b1 \u03c0\u03b1\u03c1\u03b1\u03c0\u03ac\u03bd\u03c9 \u03ba\u03b1\u03b8\u03b9\u03c3\u03c4\u03bf\u03cd\u03bd \u03c4\u03bf\u03bd EPCR \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc \u03c3\u03c4\u03cc\u03c7\u03bf \u03c4\u03c9\u03bd aPL \u03c0\u03bf\u03c5 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03b8\u03c1\u03cc\u03bc\u03b2\u03c9\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03b1\u03c5\u03c4\u03cc\u03bc\u03b1\u03c4\u03b5\u03c2 \u03b1\u03c0\u03bf\u03b2\u03bf\u03bb\u03ad\u03c2.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-weight: 400;\">\u039f \u03c0\u03b1\u03b8\u03bf\u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc\u03c2 \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc\u03c2 \u03bc\u03ad\u03c3\u03c9 \u03c4\u03bf\u03c5 \u03bf\u03c0\u03bf\u03af\u03bf\u03c5 \u03c4\u03b1 \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03b1\u03c5\u03c4\u03ac \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03bf\u03cd\u03bd 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\u03b5\u03bb\u03b1\u03c4\u03c4\u03ce\u03c3\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u03bf\u03c1\u03bc\u03bf\u03bd\u03ce\u03bd \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03c4\u03c1\u03bf\u03c6\u03bf\u03b2\u03bb\u03ac\u03c3\u03c4\u03b7 \u03ba\u03b1\u03b9 \u03bd\u03b1 \u03bf\u03b4\u03b7\u03b3\u03ae\u03c3\u03bf\u03c5\u03bd \u03ad\u03c4\u03c3\u03b9 \u03c3\u03b5 \u03c0\u03bb\u03b1\u03ba\u03bf\u03c5\u03bd\u03c4\u03b9\u03b1\u03ba\u03ae \u03b1\u03bd\u03b5\u03c0\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03ba\u03b1\u03b9 \u03b1\u03c5\u03c4\u03cc\u03bc\u03b1\u03c4\u03b5\u03c2 \u03b1\u03c0\u03bf\u03b2\u03bf\u03bb\u03ad\u03c2. \u03a4\u03b1 \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 anti- \u03b22-GPI Abs \u03c3\u03c5\u03bd\u03b4\u03b5\u03cc\u03bc\u03b5\u03bd\u03b1 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03b22-GPI \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03c6\u03ac\u03bd\u03b5\u03b9\u03b1 \u03c4\u03b7\u03c2 \u03c4\u03c1\u03bf\u03c6\u03bf\u03b2\u03bb\u03ac\u03c3\u03c4\u03b7\u03c2 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03b1\u03bd\u03b1\u03c3\u03c4\u03b5\u03af\u03bb\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03ad\u03ba\u03ba\u03c1\u03b9\u03c3\u03b7 \u03b3\u03bf\u03bd\u03b1\u03b4\u03bf\u03c4\u03c1\u03bf\u03c0\u03af\u03bd\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03b9\u03ba\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b4\u03b9\u03b5\u03af\u03c3\u03b4\u03c5\u03c3\u03ae\u03c2 \u03c4\u03b7\u03c2. \u0391\u03c5\u03c4\u03cc\u03c2 \u03bf \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc\u03c2 \u03ad\u03c7\u03b5\u03b9 \u03b5\u03bd\u03bf\u03c7\u03bf\u03c0\u03bf\u03b9\u03b7\u03b8\u03b5\u03af \u03b3\u03b9\u03b1 \u03b1\u03c0\u03bf\u03b2\u03bf\u03bb\u03ad\u03c2 \u03c3\u03b5 \u03b1\u03c1\u03c7\u03b9\u03ba\u03ac \u03c3\u03c4\u03ac\u03b4\u03b9\u03b1 \u03ba\u03cd\u03b7\u03c3\u03b7\u03c2, \u03c0\u03c1\u03ce\u03c4\u03bf\u03c5 \u03c4\u03c1\u03b9\u03bc\u03ae\u03bd\u03bf\u03c5.\u00a0\u00a0<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-weight: 400;\">\u039f\u03b9 \u03b3\u03c5\u03bd\u03b1\u03af\u03ba\u03b5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 APS \u03ba\u03b1\u03b9 \u03c0\u03c1\u03bf\u03c3\u03b2\u03bf\u03bb\u03ae \u03c4\u03c9\u03bd \u03bd\u03b5\u03c6\u03c1\u03ce\u03bd \u03b1\u03c0\u03cc \u03c4\u03b1 \u03b1\u03bd\u03c4\u03b9\u03c6\u03c9\u03c3\u03c6\u03bf\u03bb\u03b9\u03c0\u03b9\u03b4\u03b9\u03ba\u03ac \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03ad\u03c7\u03bf\u03c5\u03bd \u03ba\u03b1\u03c4\u03ac \u03ba\u03b1\u03bd\u03cc\u03bd\u03b1 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 \u03b1\u03c1\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ae \u03c0\u03af\u03b5\u03c3\u03b7, \u03b3\u03b5\u03b3\u03bf\u03bd\u03cc\u03c2 \u03c0\u03bf\u03c5 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03ad\u03bd\u03b1\u03bd \u03b5\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd \u03c3\u03bf\u03b2\u03b1\u03c1\u03cc \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b5\u03b3\u03ba\u03c5\u03bc\u03bf\u03c3\u03cd\u03bd\u03b7 \u03c4\u03bf\u03c5\u03c2 \u03ba\u03b1\u03b9 \u03c0\u03bf\u03c5 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03bf\u03b4\u03b7\u03b3\u03ae\u03c3\u03b5\u03b9 \u03c3\u03c4\u03b9\u03c2 \u03b5\u03c0\u03b9\u03c0\u03bb\u03bf\u03ba\u03ad\u03c2 \u03c0\u03bf\u03c5 \u03b1\u03bd\u03b1\u03c6\u03ad\u03c1\u03b8\u03b7\u03ba\u03b1\u03bd \u03b1\u03bd\u03c9\u03c4\u03ad\u03c1\u03c9.\u00a0<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-weight: 400;\">\u03a4\u03bf 1% \u03c4\u03c9\u03bd \u03b3\u03c5\u03bd\u03b1\u03b9\u03ba\u03ce\u03bd \u03b1\u03bd\u03b1\u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03b9\u03ba\u03ae\u03c2 \u03b7\u03bb\u03b9\u03ba\u03af\u03b1\u03c2 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03b9\u03ac\u03b6\u03bf\u03c5\u03bd \u03ba\u03b1\u03b8\u2019 \u03ad\u03be\u03b9\u03bd \u03b1\u03c0\u03bf\u03b2\u03bf\u03bb\u03ad\u03c2, \u03ba\u03b1\u03b9 \u03c0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5 10-15% \u03b1\u03c0\u03cc \u03b1\u03c5\u03c4\u03ad\u03c2 \u03b5\u03ba\u03c4\u03b9\u03bc\u03ac\u03c4\u03b1\u03b9 \u03cc\u03c4\u03b9 \u03c0\u03ac\u03c3\u03c7\u03bf\u03c5\u03bd \u03b1\u03c0\u03cc \u03bc\u03b1\u03b9\u03b5\u03c5\u03c4\u03b9\u03ba\u03cc APS. \u0398\u03b5\u03c4\u03b9\u03ba\u03cc \u03b1\u03bd\u03c4\u03b9\u03c0\u03b7\u03ba\u03c4\u03b9\u03ba\u03cc \u03c4\u03bf\u03c5 \u03bb\u03cd\u03ba\u03bf\u03c5 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf \u03b9\u03c3\u03c7\u03c5\u03c1\u03cc\u03c4\u03b5\u03c1\u03bf\u03c2 \u03c0\u03c1\u03bf\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03cc\u03c2 \u03c0\u03b1\u03c1\u03ac\u03b3\u03c9\u03bd \u03b3\u03b9\u03b1 \u03b8\u03c1\u03cc\u03bc\u03b2\u03c9\u03c3\u03b7 \u03c3\u03b5 \u03b1\u03bc\u03b9\u03b3\u03ce\u03c2 \u03bc\u03b1\u03b9\u03b5\u03c5\u03c4\u03b9\u03ba\u03cc APS \u03bc\u03b5 \u03b5\u03c4\u03ae\u03c3\u03b9\u03b1 \u03b5\u03c0\u03af\u03c0\u03c4\u03c9\u03c3\u03b7 \u03b5\u03bd \u03c4\u03c9 \u03b2\u03ac\u03b8\u03b5\u03b9 \u03c6\u03bb\u03b5\u03b2\u03bf\u03b8\u03c1\u03cc\u03bc\u03b2\u03c9\u03c3\u03b7\u03c2 1,46%, \u03ba\u03b1\u03b9 \u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03bf\u03cd \u03b5\u03b3\u03ba\u03b5\u03c6\u03b1\u03bb\u03b9\u03ba\u03bf\u03cd \u03b5\u03c0\u03b5\u03b9\u03c3\u03bf\u03b4\u03af\u03bf\u03c5 0,32%.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-weight: 400;\">\u03a3\u03c4\u03cc\u03c7\u03bf\u03c2 \u03c4\u03c9\u03bd aPL \u03b5\u03af\u03bd\u03b1\u03b9 \u03ba\u03b1\u03b9\u00a0\u03bf \u03b9\u03c3\u03c4\u03b9\u03ba\u03cc\u03c2 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03ae\u03c2 \u03c0\u03bb\u03b1\u03c3\u03bc\u03b9\u03bd\u03bf\u03b3\u03cc\u03bd\u03bf\u03c5 t-PA\u00a0. \u039f t-PA \u03bc\u03b5\u03c4\u03ad\u03c7\u03b5\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b9\u03bd\u03c9\u03b4\u03cc\u03bb\u03c5\u03c3\u03b7, \u03c3\u03c5\u03bd\u03c4\u03af\u03b8\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b1 \u03b5\u03bd\u03b4\u03bf\u03b8\u03b7\u03bb\u03b9\u03b1\u03ba\u03ac \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03ba\u03b1\u03b9 \u03b5\u03ba\u03ba\u03c1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf \u03c0\u03bb\u03ac\u03c3\u03bc\u03b1. \u0397 \u03b4\u03c1\u03ac\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b5\u03bd\u03b9\u03c3\u03c7\u03cd\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03b7 \u03c3\u03cd\u03bd\u03b4\u03b5\u03c3\u03ae \u03c4\u03bf\u03c5 \u03c3\u03c4\u03bf \u03b9\u03bd\u03ce\u03b4\u03b5\u03c2. \u0395\u03c0\u03bf\u03bc\u03ad\u03bd\u03c9\u03c2 \u03c4\u03b1 \u03b1\u03bd\u03c4\u03b9 t-PA \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03c0\u03bf\u03c5 \u03b2\u03c1\u03af\u03c3\u03ba\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b1 \u03c3\u03b5 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2 \u03b1\u03bd\u03c4\u03b9\u03c6\u03c9\u03c3\u03c6\u03bf\u03bb\u03b9\u03c0\u03b9\u03b4\u03b9\u03ba\u03bf\u03cd \u03c3\u03c5\u03bd\u03b4\u03c1\u03cc\u03bc\u03bf\u03c5, \u03c0\u03b1\u03c1\u03b5\u03bc\u03c0\u03bf\u03b4\u03af\u03b6\u03bf\u03c5\u03bd \u03c4\u03b7 \u03b4\u03c1\u03ac\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03bf\u03b4\u03b7\u03b3\u03bf\u03cd\u03bd \u03c3\u03b5 \u03c5\u03c0\u03bf\u03ca\u03bd\u03c9\u03b4\u03bf\u03bb\u03c5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2 (\u03c5\u03c0\u03b5\u03c1\u03c0\u03b7\u03ba\u03c4\u03b9\u03ba\u03ad\u03c2).<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-weight: 400;\">\u039c\u03af\u03b1 \u03ac\u03bb\u03bb\u03b7 \u03b8\u03b5\u03c9\u03c1\u03af\u03b1 \u03b5\u03c3\u03c4\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd\u00a0\u03bf\u03be\u03b5\u03b9\u03b4\u03c9\u03c4\u03b9\u03ba\u03ae \u03b2\u03bb\u03ac\u03b2\u03b7 \u03c4\u03bf\u03c5 \u03b5\u03bd\u03b4\u03bf\u03b8\u03b7\u03bb\u03af\u03bf\u03c5 \u03c4\u03c9\u03bd \u03b1\u03b3\u03b3\u03b5\u03af\u03c9\u03bd. \u0397 \u03bf\u03be\u03b5\u03b9\u03b4\u03c9\u03bc\u03ad\u03bd\u03b7 LDL (ox-LDL), \u03c0\u03bf\u03c5 \u03c3\u03c5\u03bc\u03b2\u03ac\u03bb\u03bb\u03b5\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b1\u03b8\u03b7\u03c1\u03bf\u03c3\u03ba\u03bb\u03ae\u03c1\u03c9\u03c3\u03b7, \u03c6\u03b1\u03b3\u03bf\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03ce\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03bc\u03b1\u03ba\u03c1\u03bf\u03c6\u03ac\u03b3\u03b1, \u03b1\u03c5\u03c4\u03ac \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03bf\u03cd\u03bd \u03b2\u03bb\u03ac\u03b2\u03b7 \u03c3\u03c4\u03b1 \u03b5\u03bd\u03b4\u03bf\u03b8\u03b7\u03bb\u03b9\u03b1\u03ba\u03ac \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1. \u039c\u03b5\u03c1\u03b9\u03ba\u03ac \u03b1\u03bd\u03c4\u03b9\u03ba\u03b1\u03c1\u03b4\u03b9\u03bf\u03bb\u03b9\u03c0\u03b9\u03bd\u03b9\u03ba\u03ac \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03c3\u03c5\u03bd\u03b4\u03ad\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03bf\u03be\u03b5\u03b9\u03b4\u03c9\u03bc\u03ad\u03bd\u03b7 \u03ba\u03b1\u03c1\u03b4\u03b9\u03bf\u03bb\u03b9\u03c0\u03af\u03bd\u03b7, \u03b5\u03bd\u03ce \u03b4\u03af\u03bd\u03bf\u03c5\u03bd \u03ba\u03b1\u03b9 \u03b4\u03b9\u03b1\u03c3\u03c4\u03b1\u03c5\u03c1\u03bf\u03cd\u03bc\u03b5\u03bd\u03b7 \u03b1\u03bd\u03c4\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03b7\u03bd ox-LDL. \u0394\u03b7\u03bb\u03b1\u03b4\u03ae \u03c4\u03b1 \u03b1\u03bd\u03c4\u03b9\u03ba\u03b1\u03c1\u03b4\u03b9\u03bf\u03bb\u03b9\u03c0\u03b9\u03bd\u03b9\u03ba\u03ac \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03b1\u03bd\u03b1\u03b3\u03bd\u03c9\u03c1\u03af\u03b6\u03bf\u03c5\u03bd \u03bf\u03be\u03b5\u03b9\u03b4\u03c9\u03bc\u03ad\u03bd\u03b1 \u03c6\u03c9\u03c3\u03c6\u03bf\u03bb\u03b9\u03c0\u03af\u03b4\u03b9\u03b1, \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03b4\u03b5\u03c3\u03bc\u03b5\u03cd\u03bf\u03c5\u03bd \u03c6\u03c9\u03c3\u03c6\u03bf\u03bb\u03b9\u03c0\u03af\u03b4\u03b9\u03b1 \u03ae \u03ba\u03b1\u03b9 \u03c4\u03b1 \u03b4\u03cd\u03bf \u03ba\u03b1\u03b9 \u03c3\u03c5\u03bd\u03b4\u03ad\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03bf \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc \u03c4\u03b7\u03c2 \u03b1\u03b8\u03b7\u03c1\u03bf\u03c3\u03ba\u03bb\u03ae\u03c1\u03c9\u03c3\u03b7\u03c2.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-weight: 400;\">\u03a5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03b1 \u03cc\u03c4\u03b9\u00a0\u03b9\u03b9\u03ba\u03ac \u03ba\u03b1\u03b9 \u03b2\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ac \u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03b1 \u03b5\u03c0\u03ac\u03b3\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae aPL \u03c3\u03b5 \u03b6\u03ce\u03b1\u00a0\u03ba\u03b1\u03b9 \u03c0\u03c1\u03bf\u03ac\u03b3\u03bf\u03c5\u03bd \u03b8\u03c1\u03bf\u03bc\u03b2\u03ce\u03c3\u03b5\u03b9\u03c2 \u03ba\u03b1\u03b9 \u03b1\u03c5\u03c4\u03cc\u03bc\u03b1\u03c4\u03b5\u03c2 \u03b1\u03c0\u03bf\u03b2\u03bf\u03bb\u03ad\u03c2 \u03ba\u03ac\u03c4\u03b9 \u03c4\u03bf \u03bf\u03c0\u03bf\u03af\u03bf \u03b4\u03b9\u03b5\u03c1\u03b5\u03c5\u03bd\u03ac\u03c4\u03b1\u03b9 \u03b1\u03bd \u03c3\u03c5\u03bc\u03b2\u03b1\u03af\u03bd\u03b5\u03b9 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03bf\u03bd \u03ac\u03bd\u03b8\u03c1\u03c9\u03c0\u03bf.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-weight: 400;\">\u03a0\u03c1\u03cc\u03c3\u03c6\u03b1\u03c4\u03b5\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03b1\u03bd\u03b1\u03b4\u03b5\u03b9\u03ba\u03bd\u03cd\u03bf\u03c5\u03bd \u03c4\u03bf\u03bd\u00a0\u03ac\u03bc\u03b5\u03c3\u03bf \u03c1\u03cc\u03bb\u03bf \u03c4\u03c9\u03bd \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03ce\u03bd \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae\u03c2 \u03b1\u03bd\u03bf\u03c3\u03af\u03b1\u03c2 \u03c3\u03c4\u03bf \u03b1\u03bd\u03c4\u03b9\u03c6\u03c9\u03c3\u03c6\u03bf\u03bb\u03b9\u03c0\u03b9\u03b4\u03b9\u03ba\u03cc \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf. \u0397 \u03b22-\u03b3\u03bb\u03c5\u03ba\u03bf\u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03b5\u03af \u03c5\u03c0\u03b5\u03c1\u03c0\u03bb\u03b1\u03c3\u03af\u03b1 \u03ba\u03b1\u03b9 \u03b4\u03b9\u03ad\u03b3\u03b5\u03c1\u03c3\u03b7 \u03c4\u03c9\u03bd \u03bc\u03bf\u03bd\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03c4\u03bf\u03c5 \u03c0\u03b5\u03c1\u03b9\u03c6\u03b5\u03c1\u03b9\u03ba\u03bf\u03cd \u03b1\u03af\u03bc\u03b1\u03c4\u03bf\u03c2, \u03bc\u03b5 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c4\u03b7\u03bd \u03ad\u03ba\u03ba\u03c1\u03b9\u03c3\u03b7 \u03b9\u03bd\u03c4\u03b5\u03c1\u03c6\u03b5\u03c1\u03cc\u03bd\u03b7\u03c2-\u03b3 \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03ad\u03c7\u03b5\u03b9 \u03c4\u03b7 \u03b4\u03c5\u03bd\u03b1\u03c4\u03cc\u03c4\u03b7\u03c4\u03b1 \u03bd\u03b1 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03b5\u03af \u03b1\u03c0\u03b5\u03c5\u03b8\u03b5\u03af\u03b1\u03c2 \u03c4\u03b1 \u03b5\u03bd\u03b4\u03bf\u03b8\u03b7\u03bb\u03b9\u03b1\u03ba\u03ac \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1.<\/span> <span style=\"font-weight: 400;\">\u0395\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd, \u03c0\u03b5\u03b9\u03c1\u03b1\u03bc\u03b1\u03c4\u03b9\u03ba\u03ad\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b4\u03b5\u03af\u03be\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03c4\u03b1 \u03b1\u03bd\u03c4\u03b9\u03c6\u03c9\u03c3\u03c6\u03bf\u03bb\u03b9\u03c0\u03b9\u03b4\u03b9\u03ba\u03ac \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03bf\u03cd\u03bd \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03b4\u03b9\u03b1\u03c6\u03cc\u03c1\u03c9\u03bd \u03bc\u03bf\u03c1\u03af\u03c9\u03bd \u03c0\u03c1\u03bf\u03c3\u03ba\u03cc\u03bb\u03bb\u03b7\u03c3\u03b7\u03c2, \u03cc\u03c0\u03c9\u03c2 \u03c4\u03bf\u03c5 VCAM-1 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 E-\u03c3\u03b5\u03bb\u03b5\u03ba\u03c4\u03af\u03bd\u03b7\u03c2, \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03c6\u03ac\u03bd\u03b5\u03b9\u03b1 \u03c4\u03c9\u03bd \u03b5\u03bd\u03b4\u03bf\u03b8\u03b7\u03bb\u03b9\u03b1\u03ba\u03ce\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03ba\u03b1\u03b8\u03ce\u03c2 \u03ba\u03b1\u03b9 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 \u03ad\u03ba\u03ba\u03c1\u03b9\u03c3\u03b7 \u03b9\u03bd\u03c4\u03b5\u03c1\u03bb\u03b5\u03c5\u03ba\u03af\u03bd\u03b7\u03c2 6 \u03b1\u03c0\u03cc \u03c4\u03b1 \u03af\u03b4\u03b9\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1.\u00a0<\/span><\/p>\n<p style=\"text-align: justify;\"><b>\u0391\u03b9\u03bc\u03bf\u03c0\u03b5\u03c4\u03b1\u03bb\u03b9\u03b1\u03ba\u03ae \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7.<\/b><span style=\"font-weight: 400;\"> \u0397 \u03c0\u03b1\u03c1\u03b1\u03c4\u03ae\u03c1\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03cd\u03c0\u03b1\u03c1\u03be\u03b7\u03c2 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03c9\u03bd \u03b5\u03c0\u03b9\u03c0\u03ad\u03b4\u03c9\u03bd \u03b8\u03c1\u03bf\u03bc\u03b2\u03bf\u03be\u03ac\u03bd\u03b7\u03c2 \u03c0\u03b1\u03c1\u03b1\u03b3\u03cc\u03bc\u03b5\u03bd\u03b7\u03c2 \u03b1\u03c0\u03cc \u03b1\u03b9\u03bc\u03bf\u03c0\u03b5\u03c4\u03ac\u03bb\u03b9\u03b1 \u03c3\u03c4\u03b1 \u03bf\u03cd\u03c1\u03b1 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03bc\u03b5 APS \u03b5\u03bd\u03af\u03c3\u03c7\u03c5\u03c3\u03b5 \u03c4\u03b7\u03bd \u03c5\u03c0\u03cc\u03b8\u03b5\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7\u03c2 \u03c4\u03c9\u03bd \u03b1\u03b9\u03bc\u03bf\u03c0\u03b5\u03c4\u03b1\u03bb\u03af\u03c9\u03bd \u03c9\u03c2 \u03c0\u03b1\u03b8\u03bf\u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc\u03c2 \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc\u03c2 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 APS.\u00a0<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-weight: 400;\">\u0397 \u03c5\u03c0\u03bf\u03bc\u03bf\u03bd\u03ac\u03b4\u03b1 GPIba \u03c4\u03bf\u03c5 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 GPIb\/IX\/V \u03c0\u03bf\u03c5 \u03b2\u03c1\u03af\u03c3\u03ba\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03c6\u03ac\u03bd\u03b5\u03b9\u03b1 \u03c4\u03c9\u03bd \u03b1\u03b9\u03bc\u03bf\u03c0\u03b5\u03c4\u03b1\u03bb\u03af\u03c9\u03bd, \u03ad\u03c7\u03b5\u03b9 \u03c6\u03b1\u03bd\u03b5\u03af \u03cc\u03c4\u03b9 \u03c3\u03c5\u03bd\u03b4\u03ad\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03b22-GPI \u03b4\u03b9\u03b1\u03bc\u03ad\u03c3\u03bf\u03c5 \u03c4\u03c9\u03bd \u03c0\u03b5\u03c1\u03b9\u03bf\u03c7\u03ce\u03bd 2 \u03ba\u03b1\u03b9 5 in vitro. H GPIba \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b5\u03af \u03c9\u03c2 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1\u03c2 \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03c6\u03ac\u03bd\u03b5\u03b9\u03b1 \u03c4\u03c9\u03bd \u03b1\u03b9\u03bc\u03bf\u03c0\u03b5\u03c4\u03b1\u03bb\u03af\u03c9\u03bd \u03ba\u03b1\u03b9 \u03bf \u03ba\u03c5\u03c1\u03b9\u03cc\u03c4\u03b5\u03c1\u03bf\u03c2 \u03c3\u03cd\u03bd\u03b4\u03b5\u03c3\u03bc\u03cc\u03c2 \u03c4\u03b7\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1\u03c2 Von Willebrand. \u0397 \u03b1\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 in vitro \u03c4\u03b7\u03c2 \u03c5\u03c0\u03bf\u03bc\u03bf\u03bd\u03ac\u03b4\u03b1\u03c2 GPIba \u03bc\u03b5 \u03c4\u03b7\u03bd \u03b22-GPI \u03b5\u03c0\u03b9\u03c4\u03c1\u03ad\u03c0\u03b5\u03b9 \u03c3\u03c4\u03bf \u03bc\u03bf\u03bd\u03bf\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03cc \u03b1\u03bd\u03c4\u03af\u03c3\u03c9\u03bc\u03b1 anti- \u03b22-GPI \u03bd\u03b1 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03ae\u03c3\u03b5\u03b9 \u03c4\u03b1 \u03b1\u03b9\u03bc\u03bf\u03c0\u03b5\u03c4\u03ac\u03bb\u03b9\u03b1, \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03ce\u03bd\u03c4\u03b1\u03c2 \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u03b8\u03c1\u03bf\u03bc\u03b2\u03bf\u03be\u03ac\u03bd\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03bc\u03bf\u03bd\u03bf\u03c0\u03b1\u03c4\u03b9\u03bf\u03cd \u03c6\u03c9\u03c3\u03c6\u03bf\u03ca\u03bd\u03bf\u03c3\u03b9\u03c4\u03af\u03b4\u03b7\u03c2-3 \u03ba\u03b9\u03bd\u03ac\u03c3\u03b7\/\u03b1\u03ba\u03c4\u03af\u03bd\u03b7\u03c2. \u03a9\u03c2 \u03b5\u03c0\u03b1\u03ba\u03cc\u03bb\u03bf\u03c5\u03b8\u03bf \u03b5\u03c0\u03ad\u03c1\u03c7\u03b5\u03c4\u03b1\u03b9 \u03b7 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03c9\u03bd \u03b1\u0399\u0399b\u03b23 \u03c4\u03c9\u03bd \u03b1\u03b9\u03bc\u03bf\u03c0\u03b5\u03c4\u03b1\u03bb\u03af\u03c9\u03bd<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-weight: 400;\"><\/span><\/p>\n<p style=\"text-align: justify;\">\n<p style=\"text-align: justify;\"><b>\u03a0\u03bf\u03b9\u03bf\u03b9 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b5\u03be\u03b5\u03c4\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 APS;<\/b><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-weight: 400;\">\u03a3\u03c4\u03b7\u03bd \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c0\u03c1\u03ac\u03be\u03b7, \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03b3\u03b9\u03b1 \u03b1\u03bd\u03c4\u03b9\u03c6\u03c9\u03c3\u03c6\u03bf\u03bb\u03b9\u03c0\u03b9\u03b4\u03b9\u03ba\u03ac \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03b8\u03b1 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 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\u03b8\u03c1\u03bf\u03bc\u03b2\u03ce\u03c3\u03b5\u03b9\u03c2 \u03c0\u03bf\u03c5 \u03c3\u03c5\u03bd\u03bf\u03b4\u03b5\u03cd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03ac\u03c4\u03c5\u03c0\u03b1 \u2013 \u03b1\u03c3\u03c5\u03bd\u03ae\u03b8\u03b9\u03c3\u03c4\u03b1 \u03c3\u03c5\u03bd\u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03bd\u03c4\u03b1 \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1, \u03ba\u03b1\u03b8\u03ce\u03c2 \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03b5 \u03b3\u03c5\u03bd\u03b1\u03af\u03ba\u03b5\u03c2 \u03bc\u03b5 \u03b9\u03c3\u03c4\u03bf\u03c1\u03b9\u03ba\u03cc \u03b1\u03c5\u03c4\u03cc\u03bc\u03b1\u03c4\u03c9\u03bd \u03b1\u03c0\u03bf\u03b2\u03bf\u03bb\u03ce\u03bd \u03cc\u03c4\u03b1\u03bd \u03b4\u03b5\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03ac\u03bb\u03bb\u03b7 \u03b5\u03bd\u03b1\u03bb\u03bb\u03b1\u03ba\u03c4\u03b9\u03ba\u03ae \u03b5\u03be\u03ae\u03b3\u03b7\u03c3\u03b7, \u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03b1\u03bd \u03bf\u03b9 \u03b5\u03ba\u03b4\u03b7\u03bb\u03ce\u03c3\u03b5\u03b9\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03c0\u03b1\u03bd\u03b1\u03bb\u03b1\u03bc\u03b2\u03b1\u03bd\u03cc\u03bc\u03b5\u03bd\u03b5\u03c2 (\u03ba\u03b1\u03b8\u2019 \u03ad\u03be\u03b9\u03bd \u03b1\u03c0\u03bf\u03b2\u03bf\u03bb\u03ad\u03c2).<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-weight: 400;\">\u03a0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b5\u03be\u03b5\u03c4\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c4\u03b1 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03bc\u03b5 \u03ad\u03bd\u03b1 \u03b1\u03c0\u03c1\u03cc\u03ba\u03bb\u03b7\u03c4\u03bf \u03b8\u03c1\u03bf\u03bc\u03b2\u03c9\u03c4\u03b9\u03ba\u03cc \u03b5\u03c0\u03b5\u03b9\u03c3\u03cc\u03b4\u03b9\u03bf &lt; 50 \u03b5\u03c4\u03ce\u03bd, \u03ba\u03b1\u03b8\u03ce\u03c2 \u03ba\u03b1\u03b9 \u03cc\u03bb\u03b1 \u03c4\u03b1 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03c0\u03bf\u03c5 \u03c3\u03b5 \u03c4\u03c5\u03c7\u03b1\u03af\u03bf \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1\u03c3\u03b1\u03bd \u03c0\u03b1\u03c1\u03ac\u03c4\u03b1\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03c7\u03c1\u03cc\u03bd\u03bf\u03c5 Aptt \u03c7\u03c9\u03c1\u03af\u03c2 \u03b1\u03af\u03c4\u03b9\u03bf.<\/span><span style=\"font-weight: 400;\"> \u0395\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd, \u03b1\u03bd\u03b5\u03be\u03ae\u03b3\u03b7\u03c4\u03b7 \u03b1\u03b9\u03bc\u03bf\u03bb\u03c5\u03c4\u03b9\u03ba\u03ae \u03b1\u03bd\u03b1\u03b9\u03bc\u03af\u03b1, \u03b8\u03c1\u03bf\u03bc\u03b2\u03bf\u03c0\u03b5\u03bd\u03af\u03b1, \u03ba\u03b1\u03b9 \u03b5\u03c0\u03b9\u03bc\u03ae\u03ba\u03c5\u03bd\u03c3\u03b7 \u03c7\u03c1\u03cc\u03bd\u03bf\u03c5 \u03bf\u03c0\u03bf\u03b9\u03b1\u03c3\u03b4\u03ae\u03c0\u03bf\u03c4\u03b5 \u03b4\u03bf\u03ba\u03b9\u03bc\u03b1\u03c3\u03af\u03b1\u03c2 \u03c0\u03ae\u03be\u03b5\u03c9\u03c2 \u03b8\u03b1 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03bd\u03b1 \u03bc\u03b1\u03c2 \u03ba\u03b1\u03c4\u03b5\u03c5\u03b8\u03cd\u03bd\u03b5\u03b9 \u03c3\u03c4\u03bf\u03bd \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf \u03b3\u03b9\u03b1 \u03b1\u03bd\u03c4\u03b9\u03c6\u03c9\u03c3\u03c6\u03bf\u03bb\u03b9\u03c0\u03b9\u03b4\u03b9\u03ba\u03ac \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-weight: 400;\">\u03a4\u03b1 \u03b1\u03bd\u03c4\u03b9\u03c6\u03c9\u03c3\u03c6\u03bf\u03bb\u03b9\u03c0\u03b9\u03b4\u03b9\u03ba\u03ac \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03bd\u03b1 \u03b1\u03bd\u03b5\u03c5\u03c1\u03b5\u03b8\u03bf\u03cd\u03bd \u03c3\u03b5 \u03bc\u03b7 \u03b8\u03c1\u03bf\u03bc\u03b2\u03c9\u03c4\u03b9\u03ba\u03ad\u03c2 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2 (\u03a0\u03af\u03bd\u03b1\u03ba\u03b1\u03c2 3).<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-weight: 400;\">\u00a0<\/span><\/p>\n<p style=\"text-align: justify;\"><b>\u0398\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1<\/b><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-weight: 400;\">\u03a3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c0\u03bf\u03c5 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b1\u03bd\u03c4\u03b9\u03c6\u03c9\u03c3\u03c6\u03bf\u03bb\u03b9\u03c0\u03b9\u03b4\u03b9\u03ba\u03ac \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03c3\u03c4\u03bf \u03c0\u03bb\u03ac\u03c3\u03bc\u03b1 \u03c4\u03bf\u03c5\u03c2 \u03b1\u03bb\u03bb\u03ac \u03b4\u03b5\u03bd \u03ad\u03c7\u03bf\u03c5\u03bd \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03c3\u03b5\u03b9 \u03ba\u03b1\u03bc\u03af\u03b1 \u03b8\u03c1\u03bf\u03bc\u03b2\u03c9\u03c4\u03b9\u03ba\u03ae \u03b5\u03c0\u03b9\u03c0\u03bb\u03bf\u03ba\u03ae\u00a0\u03ba\u03b1\u03b9 \u03ba\u03b1\u03bd\u03ad\u03bd\u03b1 \u03ac\u03bb\u03bb\u03bf \u03c3\u03cd\u03bc\u03c0\u03c4\u03c9\u03bc\u03b1 \u03c4\u03bf\u03c5 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\u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03b9 \u03c4\u03b7 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u03b7\u03c0\u03b1\u03c1\u03af\u03bd\u03b7\u03c2 \u03ae \u03b7\u03c0\u03b1\u03c1\u03af\u03bd\u03b7\u03c2 \u03c7\u03b1\u03bc\u03b7\u03bb\u03bf\u03cd \u03bc\u03bf\u03c1\u03b9\u03b1\u03ba\u03bf\u03cd \u03b2\u03ac\u03c1\u03bf\u03c5\u03c2 \u03b1\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03bf\u03cd\u03bc\u03b5\u03bd\u03b7 \u03c3\u03c4\u03b7 \u03c3\u03c5\u03bd\u03ad\u03c7\u03b5\u03b9\u03b1 \u03b1\u03c0\u03cc \u03ba\u03bf\u03c5\u03bc\u03b1\u03c1\u03b9\u03bd\u03b9\u03ba\u03ac \u03b1\u03bd\u03c4\u03b9\u03c0\u03b7\u03ba\u03c4\u03b9\u03ba\u03ac \u03bc\u03b5 \u03c3\u03c4\u03cc\u03c7\u03bf \u03c4\u03b7 \u03b4\u03b9\u03b1\u03c4\u03ae\u03c1\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 INR (International Normalized Ratio) \u03c0\u03ac\u03bd\u03c9 \u03b1\u03c0\u03cc 2,0 (2,0 &lt; INR &lt; 2,9).\u00a0 \u03a3\u03b7\u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03c4\u03b1\u03b9 \u03cc\u03c4\u03b9 \u03c4\u03b1 \u03ba\u03bf\u03c5\u03bc\u03b1\u03c1\u03b9\u03bd\u03b9\u03ba\u03ac \u03b1\u03bd\u03c4\u03b9\u03c0\u03b7\u03ba\u03c4\u03b9\u03ba\u03ac \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b1\u03c0\u03bf\u03c6\u03b5\u03cd\u03b3\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03ba\u03cd\u03b7\u03c3\u03b7, \u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03c3\u03c4\u03bf \u03b4\u03b9\u03ac\u03c3\u03c4\u03b7\u03bc\u03b1 \u03bc\u03b5\u03c4\u03b1\u03be\u03cd 6 \u03ba\u03b1\u03b9 12 \u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03c9\u03bd \u03ba\u03cd\u03b7\u03c3\u03b7\u03c2, \u03b4\u03b9\u03cc\u03c4\u03b9 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03bf\u03cd\u03bd \u03c4\u03b5\u03c1\u03b1\u03c4\u03bf\u03b3\u03ad\u03bd\u03b5\u03c3\u03b7. \u039f\u03b9 \u03b3\u03c5\u03bd\u03b1\u03af\u03ba\u03b5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c0\u03bf\u03c5 \u03bb\u03ac\u03bc\u03b2\u03b1\u03bd\u03b1\u03bd \u03ba\u03bf\u03c5\u03bc\u03b1\u03c1\u03b9\u03bd\u03b9\u03ba\u03ac \u03b1\u03bd\u03c4\u03b9\u03c0\u03b7\u03ba\u03c4\u03b9\u03ba\u03ac \u03bb\u03cc\u03b3\u03c9 \u03c0\u03c1\u03bf\u03b7\u03b3\u03bf\u03cd\u03bc\u03b5\u03bd\u03bf\u03c5 \u03b8\u03c1\u03bf\u03bc\u03b2\u03c9\u03c4\u03b9\u03ba\u03bf\u03cd \u03b5\u03c0\u03b5\u03b9\u03c3\u03bf\u03b4\u03af\u03bf\u03c5 \u03c0\u03c1\u03b9\u03bd \u03c4\u03b7\u03bd \u03ba\u03cd\u03b7\u03c3\u03b7 \u03b1\u03bb\u03bb\u03ac\u03b6\u03bf\u03c5\u03bd \u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c4\u03bf\u03c5\u03c2 \u03c3\u03b5 \u03b7\u03c0\u03b1\u03c1\u03af\u03bd\u03b7 \u03ae \u03b7\u03c0\u03b1\u03c1\u03af\u03bd\u03b7 \u03c7\u03b1\u03bc\u03b7\u03bb\u03bf\u03cd \u03bc\u03bf\u03c1\u03b9\u03b1\u03ba\u03bf\u03cd \u03b2\u03ac\u03c1\u03bf\u03c5\u03c2 (LMWH). \u0391\u03bd\u03c4\u03af\u03c3\u03c4\u03bf\u03b9\u03c7\u03b1, \u03c3\u03b5 \u03b3\u03c5\u03bd\u03b1\u03af\u03ba\u03b5\u03c2 \u03bc\u03b5 \u03b8\u03b5\u03c4\u03b9\u03ba\u03b1 aPL \u03c0\u03bf\u03c5 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03b3\u03ba\u03c5\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b9\u03c3\u03c4\u03bf\u03c1\u03b9\u03ba\u03cc \u03ba\u03b1\u03b8\u2019 \u03ad\u03be\u03b9\u03bd \u03b1\u03c0\u03bf\u03b2\u03bf\u03bb\u03ce\u03bd\u00a0\u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03c7\u03bf\u03c1\u03b7\u03b3\u03ae\u03c3\u03bf\u03c5\u03bc\u03b5 \u03b1\u03bd\u03c4\u03b9\u03c0\u03b7\u03ba\u03c4\u03b9\u03ba\u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1. \u039f \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc\u03c2 \u03c0\u03bf\u03c5 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7\u03c0\u03b1\u03c1\u03af\u03bd\u03b7 \u03c7\u03b1\u03bc\u03b7\u03bb\u03bf\u03cd \u03bc\u03bf\u03c1\u03b9\u03b1\u03ba\u03bf\u03cd \u03b2\u03ac\u03c1\u03bf\u03c5\u03c2 \u03ae\/ \u03ba\u03b1\u03b9 \u03bc\u03b9\u03ba\u03c1\u03ad\u03c2 \u03b4\u03cc\u03c3\u03b5\u03b9\u03c2 \u03b1\u03c3\u03c0\u03b9\u03c1\u03af\u03bd\u03b7\u03c2 (ASA). \u03a4\u03bf fondaparinux \u03b4\u03b5\u03bd \u03ad\u03c7\u03b5\u03b9 \u03b1\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03bf \u03c3\u03c5\u03bc\u03c0\u03bb\u03ae\u03c1\u03c9\u03bc\u03b1 \u03ba\u03b1\u03b9 \u03c0\u03b9\u03b8\u03b1\u03bd\u03ac \u03b4\u03b5\u03bd \u03c0\u03bb\u03b5\u03bf\u03bd\u03b5\u03ba\u03c4\u03b5\u03af \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 \u03c4\u03c9\u03bd LMWH \u03b1\u03bb\u03bb\u03ac \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b7\u03b8\u03b5\u03af \u03c3\u03b5 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2 \u03b8\u03c1\u03bf\u03bc\u03b2\u03bf\u03c0\u03b5\u03bd\u03af\u03b1\u03c2 \u03b1\u03c0\u03cc \u03b7\u03c0\u03b1\u03c1\u03af\u03bd\u03b7. \u03a4\u03b1 \u03bd\u03ad\u03b1\u03c2 \u03b3\u03b5\u03bd\u03b9\u03ac\u03c2 \u03b1\u03c0\u03cc \u03c4\u03bf\u03c5 \u03c3\u03c4\u03cc\u03bc\u03b1\u03c4\u03bf\u03c2 \u03b1\u03bd\u03c4\u03b9\u03c0\u03b7\u03ba\u03c4\u03b9\u03ba\u03ac (NOACs) \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03bc\u03b5\u03c4\u03b1\u03b2\u03ac\u03bb\u03bb\u03bf\u03c5\u03bd \u03c4\u03bf \u03c4\u03bf\u03c0\u03af\u03bf \u03c3\u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03b1\u03bd\u03c4\u03b9\u03bc\u03b5\u03c4\u03ce\u03c0\u03b9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b8\u03c1\u03bf\u03bc\u03b2\u03bf\u03b5\u03bc\u03b2\u03bf\u03bb\u03b9\u03ba\u03ae\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5, \u03c9\u03c3\u03c4\u03cc\u03c3\u03bf \u03c3\u03c4\u03bf APS -\u03bb\u03cc\u03b3\u03c9 \u03ad\u03bb\u03bb\u03b5\u03b9\u03c8\u03b7\u03c2 \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03c9\u03bd- \u03b8\u03b1 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03ba\u03b1\u03bd\u03b5\u03af\u03c2 \u03bd\u03b1 \u03b5\u03be\u03b5\u03c4\u03ac\u03b6\u03b5\u03b9 \u03c4\u03b7 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5\u03c2\u00a0 \u03bc\u03cc\u03bd\u03bf \u03c3\u03b5 \u03c0\u03b5\u03c1\u03af\u03c0\u03c4\u03c9\u03c3\u03b7 \u03b4\u03c5\u03c3\u03b1\u03bd\u03b5\u03be\u03af\u03b1\u03c2 \u03ae \u03bc\u03b7 \u03b9\u03ba\u03b1\u03bd\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03bf\u03cd \u03b1\u03bd\u03c4\u03b9\u03c0\u03b7\u03ba\u03c4\u03b9\u03ba\u03bf\u03cd \u03b5\u03bb\u03ad\u03b3\u03c7\u03bf\u03c5.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-weight: 400;\">\u0386\u03bb\u03bb\u03b5\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b5\u03c2 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03bf\u03cd\u03bd \u03b7 \u03b5\u03bd\u03b4\u03bf\u03c6\u03bb\u03ad\u03b2\u03b9\u03b1 \u03b3-\u03c3\u03c6\u03b1\u03b9\u03c1\u03af\u03bd\u03b7, \u03c0\u03bf\u03c5 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b7\u03b8\u03b5\u03af \u03c3\u03b5 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03c0\u03bf\u03c5 \u03c3\u03c5\u03bd\u03b5\u03c7\u03af\u03b6\u03bf\u03c5\u03bd \u03bd\u03b1 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b1\u03c5\u03c4\u03cc\u03bc\u03b1\u03c4\u03b5\u03c2 \u03b1\u03c0\u03bf\u03b2\u03bf\u03bb\u03ad\u03c2 \u03c0\u03b1\u03c1\u03ac \u03c4\u03bf \u03b3\u03b5\u03b3\u03bf\u03bd\u03cc\u03c2 \u03cc\u03c4\u03b9 \u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03c5\u03bd \u03b7\u03c0\u03b1\u03c1\u03af\u03bd\u03b7 \u03ba\u03b1\u03b9 ASA \u03ba\u03b1\u03b9 \u03b7 \u03c0\u03bb\u03b1\u03c3\u03bc\u03b1\u03c6\u03b1\u03af\u03c1\u03b5\u03c3\u03b7 \u03c0\u03bf\u03c5 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03c1\u03bf\u03c6\u03b9\u03ba\u03bf\u03cd APS \u03c3\u03b5 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc \u03bc\u03b5 \u03b1\u03bd\u03c4\u03b9\u03c0\u03b7\u03ba\u03c4\u03b9\u03ba\u03ae \u03b1\u03b3\u03c9\u03b3\u03ae. \u03a4\u03bf \u03c7\u03b9\u03bc\u03b1\u03b9\u03c1\u03b9\u03ba\u03cc \u03bc\u03bf\u03bd\u03bf\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03cc \u03b1\u03bd\u03c4\u03af\u03c3\u03c9\u03bc\u03b1 \u03b1\u03bd\u03c4\u03b9-CD20, Rituximab, \u03ad\u03c7\u03b5\u03b9 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b7\u03b8\u03b5\u03af \u03b5\u03ba\u03c4\u03cc\u03c2 \u03b5\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03c9\u03bd (off label) \u03c3\u03b5 APS \u03bc\u03b5 \u03c3\u03bf\u03b2\u03b1\u03c1\u03ae \u03b8\u03c1\u03bf\u03bc\u03b2\u03bf\u03c0\u03b5\u03bd\u03af\u03b1, \u03b1\u03b9\u03bc\u03bf\u03bb\u03c5\u03c4\u03b9\u03ba\u03ae \u03b1\u03bd\u03b1\u03b9\u03bc\u03af\u03b1, \u03b4\u03b5\u03c1\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac \u03ad\u03bb\u03ba\u03b7 \u03ba\u03b1\u03b9 \u03bd\u03ad\u03ba\u03c1\u03c9\u03c3\u03b7 \u03ba\u03b1\u03b8\u03ce\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03b5 CAPS \u03bc\u03b5 \u03c0\u03bf\u03b9\u03ba\u03af\u03bb\u03b5\u03c2 \u03b1\u03c0\u03b1\u03bd\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-weight: 400;\">\u039c\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 \u03bc\u03b5 \u03b1\u03c0\u03ce\u03bb\u03b5\u03b9\u03b1 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03c3\u03b5 \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b5\u03c2 \u03c4\u03bf\u03c5 \u03c3\u03c5\u03bc\u03c0\u03bb\u03b7\u03c1\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2 \u03bf\u03b4\u03b7\u03b3\u03bf\u03cd\u03bd \u03c3\u03c4\u03bf \u03ac\u03c4\u03c5\u03c0\u03bf \u03bf\u03c5\u03c1\u03b1\u03b9\u03bc\u03b9\u03ba\u03cc \u03b1\u03b9\u03bc\u03bf\u03bb\u03c5\u03c4\u03b9\u03ba\u03cc \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf (aHUS), \u03c3\u03c4\u03b7\u03bd \u03c0\u03c1\u03bf\u03b5\u03ba\u03bb\u03b1\u03bc\u03c8\u03af\u03b1 \u03ba\u03b1\u03b9\u00a0 \u03c3\u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03bf\u03be\u03c5\u03c3\u03bc\u03b9\u03ba\u03ae \u03bd\u03c5\u03c7\u03c4\u03b5\u03c1\u03b9\u03bd\u03ae \u03b1\u03b9\u03bc\u03bf\u03c3\u03c6\u03b1\u03b9\u03c1\u03b9\u03bd\u03bf\u03c5\u03c1\u03af\u03b1 (PNH). \u03a4\u03b1 \u03bd\u03bf\u03c3\u03ae\u03bc\u03b1\u03c4\u03b1 \u03b1\u03c5\u03c4\u03ac \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b5\u03bd\u03b4\u03bf\u03b8\u03b7\u03bb\u03b9\u03b1\u03ba\u03ce\u03bd \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03c9\u03bd \u03c4\u03c9\u03bd \u03bc\u03b9\u03ba\u03c1\u03ce\u03bd \u03b1\u03b3\u03b3\u03b5\u03af\u03c9\u03bd, \u03c0\u03bf\u03c5 \u03bf\u03b4\u03b7\u03b3\u03b5\u03af \u03c3\u03b5\u00a0 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae \u03b2\u03bb\u03ac\u03b2\u03b7 \u03ba\u03b1\u03b9 \u03b8\u03c1\u03cc\u03bc\u03b2\u03c9\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03b1\u03bd\u03c4\u03b9\u03bc\u03b5\u03c4\u03c9\u03c0\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03bf eculizumab.\u00a0<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-weight: 400;\">\u0391\u03bd\u03c4\u03af\u03c3\u03c4\u03bf\u03b9\u03c7\u03b1, \u03c3\u03c4\u03b7 \u03b2\u03bb\u03ac\u03b2\u03b7 \u03c4\u03b7\u03c2 \u03c4\u03c1\u03bf\u03c6\u03bf\u03b2\u03bb\u03ac\u03c3\u03c4\u03b7\u03c2 \u03c0\u03b1\u03af\u03b6\u03bf\u03c5\u03bd \u03c1\u03cc\u03bb\u03bf \u03b7 \u03c0\u03c1\u03bf\u03c3\u03ad\u03bb\u03ba\u03c5\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd \u03bf\u03c5\u03b4\u03b5\u03c4\u03b5\u03c1\u03bf\u03c6\u03af\u03bb\u03c9\u03bd \u03c0\u03bf\u03c5 \u03b5\u03c0\u03ac\u03b3\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03bf C5a \u03ba\u03b1\u03b9 \u03b1\u03bd\u03b1\u03c3\u03c4\u03ad\u03bb\u03bb\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b1 \u03b1\u03bd\u03c4\u03b9-C5 \u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03b1 \u03c0\u03bf\u03c5 \u03bc\u03c0\u03bb\u03bf\u03ba\u03ac\u03c1\u03bf\u03c5\u03bd \u03c4\u03bf\u03bd C5aR. \u0397 aPL-\u03b5\u03c0\u03b1\u03b3\u03ce\u03bc\u03b5\u03bd\u03b7 \u03c0\u03bb\u03b1\u03ba\u03bf\u03c5\u03bd\u03c4\u03b9\u03b1\u03ba\u03ae \u03b1\u03bd\u03b5\u03c0\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1, \u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ae \u03ba\u03b1\u03b9 \u03b8\u03c1\u03cc\u03bc\u03b2\u03c9\u03c3\u03b7 \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c4\u03b7\u03bd \u03b1\u03bb\u03bb\u03b7\u03bb\u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03c4\u03bf\u03c5 C5a \u03ba\u03b1\u03b9 \u03c4\u03bf\u03c5 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 \u03c4\u03bf\u03c5. \u0388\u03bb\u03bb\u03b5\u03b9\u03c8\u03b7 \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03c4\u03b9\u03ba\u03ce\u03bd \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03ce\u03bd \u03c4\u03bf\u03c5 \u03c3\u03c5\u03bc\u03c0\u03bb\u03b7\u03c1\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2 \u03c3\u03b5 \u03bc\u03bf\u03bd\u03c4\u03ad\u03bb\u03b1 \u03c0\u03bf\u03bd\u03c4\u03b9\u03ba\u03ce\u03bd \u03bf\u03b4\u03b7\u03b3\u03b5\u03af \u03c3\u03b5 \u03bc\u03b9\u03ba\u03c1\u03bf\u03b1\u03b3\u03b3\u03b5\u03b9\u03bf\u03c0\u03ac\u03b8\u03b5\u03b9\u03b1 \u03ba\u03b1\u03b9 \u03b1\u03c0\u03bf\u03b2\u03bf\u03bb\u03ae \u03b5\u03bc\u03b2\u03c1\u03cd\u03bf\u03c5, \u03b5\u03bd\u03ce \u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bc\u03b5 \u03c4\u03bf \u03b1\u03bd\u03c4\u03b9-C5 \u03b1\u03bd\u03c4\u03af\u03c3\u03c9\u03bc\u03b1 eculizumab \u03ae \u03bc\u03b5 \u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03b1 \u03c0\u03bf\u03c5 \u03b4\u03b5\u03c3\u03bc\u03b5\u03cd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf\u03bd C5aR \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b1\u00a0 \u03c0\u03b1\u03c1\u03b5\u03bc\u03c0\u03bf\u03b4\u03af\u03b6\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7 \u03b8\u03c1\u03cc\u03bc\u03b2\u03c9\u03c3\u03b7\u03c2 \u03c3\u03b5 \u03c0\u03bf\u03bd\u03c4\u03af\u03ba\u03b9\u03b1 \u03c0\u03bf\u03c5 \u03c0\u03ac\u03c3\u03c7\u03bf\u03c5\u03bd \u03b1\u03c0\u03cc APS.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-weight: 400;\"><\/span><\/p>\n<p style=\"text-align: justify;\">\n<p style=\"text-align: justify;\"><b>\u0391\u03b3\u03b3\u03bb\u03b9\u03ba\u03ae \u03c0\u03b5\u03c1\u03af\u03bb\u03b7\u03c8\u03b7<\/b><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-weight: 400;\">\u00a0<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-weight: 400;\">The term thrombophilia (origin from Greek &#8220;\u03c6\u03b9\u03bb\u03b5\u03af \u03c4\u03bf\u03bd \u03b8\u03c1\u03cc\u03bc\u03b2\u03bf&#8221; = friend of thrombus) describes the predisposition to venous thromboembolism and, under certain circumstances, also an increased risk of arterial thrombosis. Antiphospholipid syndrome (APS) is an autoimmune multisystem disorder characterized by arterial, venous, or small vessel thromboembolic events and\/or pregnancy morbidity in the presence of persistent antiphospholipid antibodies (aPL). aPLs are a heterogenous group of autoantibodies which are directed against phospholipid-binding proteins like Lupus Anticoagulant (LA), anti &#8211; Cardiolipin (aCL) and Anti-\u03b22-GPI antibodies. The underlying mechanisms of APS syndrome, venous and arterial thrombosis and recurrent pregnancy loss are still under investigation but there are some candidate pathogenetic mechanisms that dictate appropriate therapeutic interventions.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-weight: 400;\"><\/span><\/p>\n<p style=\"text-align: justify;\">\n<p style=\"text-align: justify;\"><b>\u0392\u03b9\u03b2\u03bb\u03b9\u03bf\u03b3\u03c1\u03b1\u03c6\u03b9\u03ba\u03ad\u03c2 \u03c0\u03b1\u03c1\u03b1\u03c0\u03bf\u03bc\u03c0\u03ad\u03c2<\/b><\/p>\n<ol style=\"text-align: justify;\">\n<li><span style=\"font-weight: 400;\"> <\/span><a href=\"https:\/\/www.uptodate.com\/contents\/clinical-manifestations-of-antiphospholipid-syndrome\/abstract\/1\"><span style=\"font-weight: 400;\">Miyakis S, Lockshin MD, Atsumi T, et al. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost 2006; 4:295<\/span><\/a><\/li>\n<\/ol>\n<p style=\"text-align: justify;\"><span style=\"font-weight: 400;\">\u00a0<\/span><\/p>\n<ol start=\"2\" style=\"text-align: justify;\">\n<li><span style=\"font-weight: 400;\"> A. Duarte-Garcia, M. Pham, C. S. Crowson, K. Moder, Rajiv Pruthi, E. L.Matteson, Epidemiology of Antiphospholipid Syndrome:A population based study, Arthritis Rheumatol,<\/span><i><span style=\"font-weight: 400;\">. <\/span><\/i><span style=\"font-weight: 400;\">2017; 69\u00a0<\/span><\/li>\n<\/ol>\n<p style=\"text-align: justify;\"><span style=\"font-weight: 400;\">\u00a0<\/span><\/p>\n<ol start=\"3\" style=\"text-align: justify;\">\n<li><span style=\"font-weight: 400;\"> Jose A. G\u00f3mez-Puerta a, b, Ricard Cervera a, * Diagnosis and classification of the antiphospholipid syndrome Journal of Autoimmunity 48-49 (2014) 20e25 Dr. Yaniv &amp; Professor Yehuda Shoenfeld The Antiphospholipid Syndrome First Edition Copyright \u00a9 2004\u00a0<\/span><\/li>\n<\/ol>\n<p style=\"text-align: justify;\"><span style=\"font-weight: 400;\">\u00a0<\/span><\/p>\n<ol start=\"4\" style=\"text-align: justify;\">\n<li><span style=\"font-weight: 400;\"> Patterson AM, Ford I, Graham A, Booth NA, Greaves M. The influence of anti-endothelial\/antiphospholipid antibodies on fibrin formation and lysis on endothelial cells. Br J Haematol 2006; 133:323\u20133\u00a0<\/span><\/li>\n<\/ol>\n<p style=\"text-align: justify;\"><span style=\"font-weight: 400;\">\u00a0<\/span><\/p>\n<ol start=\"5\" style=\"text-align: justify;\">\n<li><span style=\"font-weight: 400;\"> Ling Q, Jacovina AT, Deora A, et al. Annexin II regulates fibrin homeostasis and neoangiogenesis in vivo. J Clin Invest 2004; 113:38\u201348\u00a0<\/span><\/li>\n<\/ol>\n<p style=\"text-align: justify;\"><span style=\"font-weight: 400;\">\u00a0<\/span><\/p>\n<ol start=\"6\" style=\"text-align: justify;\">\n<li><span style=\"font-weight: 400;\"> Bevers EM, Zwaal RF, Willems GM. The effect of phospholipids on the formation of immune complexes between autoantibodies and beta2-glycoprotein I or prothrombin. Clin Immunol 2004; 112:150\u2013160\u00a0<\/span><\/li>\n<\/ol>\n<p style=\"text-align: justify;\"><span style=\"font-weight: 400;\">\u00a0<\/span><\/p>\n<ol start=\"7\" style=\"text-align: justify;\">\n<li><span style=\"font-weight: 400;\"> Galli M, Willems GM, Rosing J, et al. Anti-prothrombin IgG from patients with anti-phospholipid antibodies inhibits the inactivation of factor Va by activated protein C. Br J Haematol 2005; 129:240\u2013247\u00a0<\/span><\/li>\n<\/ol>\n<p style=\"text-align: justify;\"><span style=\"font-weight: 400;\">\u00a0<\/span><\/p>\n<ol start=\"8\" style=\"text-align: justify;\">\n<li><span style=\"font-weight: 400;\"> Shi T, Iverson GM, Qi JC, et al. Beta 2-glycoprotein I binds factor XI and inhibits its activation by thrombin and factor XIIa: loss of inhibition by clipped beta 2-glycoprotein I. Proc Natl Acad Sci U S A 2004; 101:3939\u20133944\u00a0<\/span><\/li>\n<\/ol>\n<p style=\"text-align: justify;\"><span style=\"font-weight: 400;\">\u00a0<\/span><\/p>\n<ol start=\"9\" style=\"text-align: justify;\">\n<li><span style=\"font-weight: 400;\"> Yasuda S, Atsumi T, Ieko M, et al. Nicked beta2-glycoprotein I: a marker of cerebral infarct and a novel role in the negative feedback pathway of extrinsic fibrinolysis. Blood 2004; 103:3766\u20133772<\/span><\/li>\n<\/ol>\n<p style=\"text-align: justify;\"><span style=\"font-weight: 400;\">\u00a0<\/span><\/p>\n<ol start=\"10\" style=\"text-align: justify;\">\n<li><span style=\"font-weight: 400;\"> Nigel Mackman, The Role of Tissue Factor and Factor VIIa in Hemostasis, Anesthesia Anesthesia and analgesia (2009) May, 108 (5):1447-1472\u00a0<\/span><\/li>\n<\/ol>\n<p style=\"text-align: justify;\"><span style=\"font-weight: 400;\">\u00a0<\/span><\/p>\n<ol start=\"11\" style=\"text-align: justify;\">\n<li><span style=\"font-weight: 400;\"> Doruk Erkan Erkan D, Lockshin MD. What is antiphospholipid syndrome? Curr Rheumatol Rep. 2004;6:451-457\u00a0<\/span><\/li>\n<\/ol>\n<p style=\"text-align: justify;\"><span style=\"font-weight: 400;\">\u00a0<\/span><\/p>\n<ol start=\"12\" style=\"text-align: justify;\">\n<li><span style=\"font-weight: 400;\"> Rai RS, Regan L, Clifford K, et al. Antiphospholipid antibodies and beta 2-glycoprotein-I in 500 women with recurrent miscarriage: results of a comprehensive screening approach. Hum Reprod. 1995;10:2001-2005<\/span><\/li>\n<\/ol>\n<p style=\"text-align: justify;\"><span style=\"font-weight: 400;\">\u00a0<\/span><\/p>\n<ol start=\"13\" style=\"text-align: justify;\">\n<li><span style=\"font-weight: 400;\"> Loizou S, Byron MA, Englert HJ, et al. Association of quantitative anticardiolipin antibody levels with fetal loss and time of loss in systemic lupus erythematosus. Q J Med. 1988;68:525-531.\u00a0<\/span><\/li>\n<li><span style=\"font-weight: 400;\"> Jara LJ, Medina G, Vera-Lastra O, et al. The impact of gender on clinical manifestations of primary antiphospholipid syndrome. Lupus. 2005;14:607-612<\/span><\/li>\n<\/ol>\n<p style=\"text-align: justify;\"><span style=\"font-weight: 400;\">\u00a0<\/span><\/p>\n<ol start=\"15\" style=\"text-align: justify;\">\n<li><span style=\"font-weight: 400;\"> A. Duarte-Garcia, M. Pham, C. S. Crowson, K. Moder, Rajiv Pruthi, E. L.Matteson, Epidemiology of Antiphospholipid Syndrome:A population based study, Arthritis Rheumatol,. 2017; 69\u00a0<\/span><\/li>\n<\/ol>\n<p style=\"text-align: justify;\">[\/et_pb_text][et_pb_text _builder_version=&#8221;4.17.4&#8243; _module_preset=&#8221;default&#8221; hover_enabled=&#8221;0&#8243; sticky_enabled=&#8221;0&#8243; text_font=&#8221;Arial||||||||&#8221;]<\/p>\n<p><b>\u03a0\u03af\u03bd\u03b1\u03ba\u03b5\u03c2<\/b><\/p>\n<p><b>\u03a0\u03af\u03bd\u03b1\u03ba\u03b1\u03c2 1: \u039f\u03b9 \u03c0\u03b9\u03bf \u03ba\u03bf\u03b9\u03bd\u03ad\u03c2 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ad\u03c2 \u03b5\u03ba\u03b4\u03b7\u03bb\u03ce\u03c3\u03b5\u03b9\u03c2 \u03c4\u03bf\u03c5 \u0391\u03bd\u03c4\u03b9\u03c6\u03c9\u03c3\u03c6\u03bf\u03bb\u03b9\u03c0\u03b9\u03b4\u03b9\u03ba\u03bf\u03cd \u03c3\u03c5\u03bd\u03b4\u03c1\u03cc\u03bc\u03bf\u03c5.<\/b><\/p>\n<table>\n<tbody>\n<tr>\n<td>\n<p><span style=\"font-weight: 400;\">\u0391\u03c1\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ad\u03c2 \u03b5\u03ba\u03b4\u03b7\u03bb\u03ce\u03c3\u03b5\u03b9\u03c2<\/span><\/p>\n<\/td>\n<td>\n<p><span style=\"font-weight: 400;\">\u0398\u03c1\u03cc\u03bc\u03b2\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b1\u03bf\u03c1\u03c4\u03ae\u03c2 \u03ae \u03c4\u03b7\u03c2 \u03bc\u03b1\u03c3\u03c7\u03b1\u03bb\u03b9\u03b1\u03af\u03b1\u03c2, \u03ba\u03b1\u03c1\u03c9\u03c4\u03b9\u03b4\u03b9\u03ba\u03ae\u03c2, \u03b7\u03c0\u03b1\u03c4\u03b9\u03ba\u03ae\u03c2, \u03bc\u03b5\u03c3\u03b5\u03bd\u03c4\u03ad\u03c1\u03b9\u03b1\u03c2 \u03c0\u03b1\u03b3\u03ba\u03c1\u03b5\u03b1\u03c4\u03b9\u03ba\u03ae\u03c2, \u03c3\u03c0\u03bb\u03b7\u03bd\u03b9\u03ba\u03ae\u03c2 \u03ae \u03c5\u03c0\u03bf\u03ba\u03bb\u03b5\u03af\u03b4\u03b9\u03b1\u03c2 \u03b1\u03c1\u03c4\u03b7\u03c1\u03af\u03b1\u03c2.<\/span><\/p>\n<\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td>\n<p><span style=\"font-weight: 400;\">\u0391\u03b9\u03bc\u03b1\u03c4\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ad\u03c2 \u03b5\u03ba\u03b4\u03b7\u03bb\u03ce\u03c3\u03b5\u03b9\u03c2<\/span><\/p>\n<\/td>\n<td>\n<p><span style=\"font-weight: 400;\">\u0398\u03c1\u03bf\u03bc\u03b2\u03bf\u03c0\u03b5\u03bd\u03af\u03b1, \u03b1\u03b9\u03bc\u03bf\u03bb\u03c5\u03c4\u03b9\u03ba\u03ae \u03b1\u03bd\u03b1\u03b9\u03bc\u03af\u03b1, \u03ae \u03b1\u03b9\u03bc\u03bf\u03bb\u03c5\u03c4\u03b9\u03ba\u03cc-\u03bf\u03c5\u03c1\u03b1\u03b9\u03bc\u03b9\u03ba\u03cc \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf \u03ba\u03b1\u03b9 \u03b8\u03c1\u03bf\u03bc\u03b2\u03c9\u03c4\u03b9\u03ba\u03ae \u03b8\u03c1\u03bf\u03bc\u03b2\u03bf\u03c0\u03b5\u03bd\u03b9\u03ba\u03ae \u03c0\u03bf\u03c1\u03c6\u03cd\u03c1\u03b1.<\/span><\/p>\n<\/td>\n<td>\n<p><span style=\"font-weight: 400;\">\u0394\u03b9\u03ac\u03c7\u03c5\u03c4\u03b7 \u03b5\u03bd\u03b4\u03bf\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ae \u03c0\u03ae\u03be\u03b7 (\u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03c1\u03bf\u03c6\u03b9\u03ba\u03cc \u03b1\u03bd\u03c4\u03b9\u03c6\u03c9\u03c3\u03c6\u03bf\u03bb\u03b9\u03c0\u03b9\u03b4\u03b9\u03ba\u03cc \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf \u03bc\u03cc\u03bd\u03bf).<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td>\n<p><span style=\"font-weight: 400;\">\u039d\u03b5\u03c5\u03c1\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ad\u03c2 \u03b5\u03ba\u03b4\u03b7\u03bb\u03ce\u03c3\u03b5\u03b9\u03c2<\/span><\/p>\n<\/td>\n<td>\n<p><span style=\"font-weight: 400;\">\u03a0\u03b1\u03c1\u03bf\u03b4\u03b9\u03ba\u03ae \u03b9\u03c3\u03c7\u03b1\u03b9\u03bc\u03b9\u03ba\u03ae \u03bd\u03cc\u03c3\u03bf\u03c2, \u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03cc \u03b5\u03b3\u03ba\u03b5\u03c6\u03b1\u03bb\u03b9\u03ba\u03cc \u03b5\u03c0\u03b5\u03b9\u03c3\u03cc\u03b4\u03b9\u03bf (\u03b8\u03c1\u03bf\u03bc\u03b2\u03c9\u03c4\u03b9\u03ba\u03cc \u03ae \u03b5\u03bc\u03b2\u03bf\u03bb\u03b9\u03ba\u03cc), \u03c7\u03bf\u03c1\u03b5\u03af\u03b1, \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03ae-\u03ad\u03bc\u03c6\u03c1\u03b1\u03ba\u03c4\u03b7 \u03ac\u03bd\u03bf\u03b9\u03b1, \u03b5\u03b3\u03ba\u03ac\u03c1\u03c3\u03b9\u03b1 \u03bc\u03c5\u03b5\u03bb\u03af\u03c4\u03b9\u03b4\u03b1, \u03b5\u03b3\u03ba\u03b5\u03c6\u03b1\u03bb\u03bf\u03c0\u03ac\u03b8\u03b5\u03b9\u03b1, \u03b7\u03bc\u03b9\u03ba\u03c1\u03b1\u03bd\u03af\u03b5\u03c2, \u03c8\u03b5\u03c5\u03b4\u03bf\u03cc\u03b3\u03ba\u03bf\u03c2 \u03b5\u03b3\u03ba\u03b5\u03c6\u03ac\u03bb\u03bf\u03c5, \u03b5\u03b3\u03ba\u03b5\u03c6\u03b1\u03bb\u03b9\u03ba\u03ae \u03c6\u03bb\u03b5\u03b2\u03b9\u03ba\u03ae \u03b8\u03c1\u03cc\u03bc\u03b2\u03c9\u03c3\u03b7, \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03ae \u03bc\u03bf\u03bd\u03bf\u03bd\u03b5\u03c5\u03c1\u03af\u03c4\u03b9\u03b4\u03b1 \u03ae amaurosis fugax.<\/span><\/p>\n<\/td>\n<td>\n<p><span style=\"font-weight: 400;\">\u039c\u03b9\u03ba\u03c1\u03bf\u03b8\u03c1\u03bf\u03bc\u03b2\u03ce\u03c3\u03b5\u03b9\u03c2 \u03ae \u03bc\u03b9\u03ba\u03c1\u03bf\u03b5\u03bc\u03c6\u03c1\u03ac\u03b3\u03bc\u03b1\u03c4\u03b1<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td>\n<p><span style=\"font-weight: 400;\">\u039c\u03b1\u03b9\u03b5\u03c5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b5\u03ba\u03b4\u03b7\u03bb\u03ce\u03c3\u03b5\u03b9\u03c2<\/span><\/p>\n<\/td>\n<td>\n<p><span style=\"font-weight: 400;\">\u0391\u03c0\u03ce\u03bb\u03b5\u03b9\u03b1 \u03ba\u03cd\u03b7\u03c3\u03b7\u03c2, \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf HELLP -\u03b1\u03b9\u03bc\u03cc\u03bb\u03c5\u03c3\u03b7, \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b1 \u03b7\u03c0\u03b1\u03c4\u03b9\u03ba\u03ac \u03ad\u03bd\u03b6\u03c5\u03bc\u03b1 \u03ba\u03b1\u03b9 \u03c7\u03b1\u03bc\u03b7\u03bb\u03cc\u03c2 \u03b1\u03c1\u03b9\u03b8\u03bc\u03cc\u03c2 \u03b1\u03b9\u03bc\u03bf\u03c0\u03b5\u03c4\u03b1\u03bb\u03af\u03c9\u03bd \u03c3\u03b5 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc \u03bc\u03b5 \u03c0\u03c1\u03bf\u03b5\u03ba\u03bb\u03b1\u03bc\u03c8\u03af\u03b1, \u03b1\u03bd\u03b5\u03c0\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03c0\u03bb\u03b1\u03ba\u03bf\u03cd\u03bd\u03c4\u03b1.<\/span><\/p>\n<\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td>\n<p><span style=\"font-weight: 400;\">\u039a\u03b1\u03c1\u03b4\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ad\u03c2<\/span> <span style=\"font-weight: 400;\">\u03b5\u03ba\u03b4\u03b7\u03bb\u03ce\u03c3\u03b5\u03b9\u03c2<\/span><\/p>\n<\/td>\n<td>\n<p><span style=\"font-weight: 400;\">\u03a3\u03c4\u03b7\u03b8\u03ac\u03b3\u03c7\u03b7, \u03ad\u03bc\u03c6\u03c1\u03b1\u03b3\u03bc\u03b1 \u03bc\u03c5\u03bf\u03ba\u03b1\u03c1\u03b4\u03af\u03bf\u03c5, \u03b2\u03b1\u03bb\u03b2\u03b9\u03b4\u03bf\u03c0\u03ac\u03b8\u03b5\u03b9\u03b5\u03c2, \u03b5\u03ba\u03b2\u03bb\u03b1\u03c3\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2, \u03b2\u03b1\u03bb\u03b2\u03b9\u03b4\u03b9\u03ba\u03ad\u03c2 \u03b1\u03bd\u03c9\u03bc\u03b1\u03bb\u03af\u03b5\u03c2, \u03bc\u03b7 \u03b2\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ae \u03b8\u03c1\u03bf\u03bc\u03b2\u03c9\u03c4\u03b9\u03ba\u03ae (Lidmam- Sacks) \u03b5\u03bd\u03b4\u03bf\u03ba\u03b1\u03c1\u03b4\u03af\u03c4\u03b9\u03b4\u03b1.<\/span><\/p>\n<\/td>\n<td>\n<p><span style=\"font-weight: 400;\">\u0388\u03bc\u03c6\u03c1\u03b1\u03b3\u03bc\u03b1 \u03bc\u03c5\u03bf\u03ba\u03b1\u03c1\u03b4\u03af\u03bf\u03c5, \u03b5\u03bd\u03b4\u03bf\u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03ba\u03bf\u03af \u03b8\u03c1\u03cc\u03bc\u03b2\u03bf\u03b9.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td>\n<p><span style=\"font-weight: 400;\">\u0394\u03b5\u03c1\u03bc\u03b1\u03c4\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ad\u03c2 \u03b5\u03ba\u03b4\u03b7\u03bb\u03ce\u03c3\u03b5\u03b9\u03c2<\/span><\/p>\n<\/td>\n<td>\n<p><span style=\"font-weight: 400;\">\u0395\u03c0\u03b9\u03c6\u03b1\u03bd\u03b5\u03b9\u03b1\u03ba\u03ae \u03b8\u03c1\u03bf\u03bc\u03b2\u03bf\u03c6\u03bb\u03b5\u03b2\u03af\u03c4\u03b9\u03b4\u03b1, \u03ad\u03bb\u03ba\u03b7 \u03ba\u03ac\u03c4\u03c9 \u03ac\u03ba\u03c1\u03c9\u03bd, \u03b4\u03b5\u03c1\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03b9\u03c3\u03c7\u03b1\u03b9\u03bc\u03af\u03b1, \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf \u03bd\u03ad\u03ba\u03c1\u03c9\u03c3\u03b7\u03c2 \u03bc\u03b5\u03b3\u03ac\u03bb\u03bf\u03c5 \u03b4\u03b1\u03ba\u03c4\u03cd\u03bb\u03bf\u03c5 (blue toe), \u03b5\u03ba\u03c7\u03c5\u03bc\u03ce\u03c3\u03b5\u03b9\u03c2, \u03ae \u03b1\u03ba\u03c1\u03bf\u03ba\u03c5\u03ac\u03bd\u03c9\u03c3\u03b7.<\/span><\/p>\n<\/td>\n<td>\n<p><span style=\"font-weight: 400;\">\u0394\u03b9\u03ba\u03c4\u03c5\u03c9\u03c4\u03ae \u03c0\u03b5\u03bb\u03af\u03c9\u03c3\u03b7, \u03b5\u03c0\u03b9\u03c6\u03b1\u03bd\u03b5\u03b9\u03b1\u03ba\u03ae \u03b3\u03ac\u03b3\u03b3\u03c1\u03b1\u03b9\u03bd\u03b1, \u03c0\u03bf\u03c1\u03c6\u03cd\u03c1\u03b1 \u03b4\u03ad\u03c1\u03bc\u03b1\u03c4\u03bf\u03c2.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td>\n<p><span style=\"font-weight: 400;\">\u0395\u03bd\u03b4\u03bf\u03ba\u03c1\u03b9\u03bd\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ad\u03c2 \u03b5\u03ba\u03b4\u03b7\u03bb\u03ce\u03c3\u03b5\u03b9\u03c2<\/span><\/p>\n<\/td>\n<td>\n<p><span style=\"font-weight: 400;\">\u0395\u03c0\u03b9\u03bd\u03b5\u03c6\u03c1\u03b9\u03b4\u03b9\u03ba\u03ac \u03b5\u03bc\u03c6\u03c1\u03ac\u03b3\u03bc\u03b1\u03c4\u03b1, \u03b5\u03c0\u03b9\u03bd\u03b5\u03c6\u03c1\u03b9\u03b4\u03b9\u03ba\u03ae \u03b1\u03bd\u03b5\u03c0\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1, \u03ad\u03bc\u03c6\u03c1\u03b1\u03ba\u03c4\u03b1 \u03cc\u03c1\u03c7\u03b5\u03c9\u03c2 \u03ba\u03b1\u03b9 \u03c0\u03c1\u03bf\u03c3\u03c4\u03ac\u03c4\u03b7, \u03bd\u03ad\u03ba\u03c1\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b2\u03bb\u03b5\u03bd\u03bd\u03bf\u03b3\u03cc\u03bd\u03b9\u03bf\u03c5 \u03b1\u03b4\u03ad\u03bd\u03b1 \u03ae \u03b2\u03bb\u03b5\u03bd\u03bd\u03bf\u03b3\u03cc\u03bd\u03b9\u03b1 \u03b1\u03bd\u03b5\u03c0\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1.<\/span><\/p>\n<\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td>\n<p><span style=\"font-weight: 400;\">\u0393\u03b1\u03c3\u03c4\u03c1\u03b5\u03bd\u03c4\u03b5\u03c1\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ad\u03c2 \u03b5\u03ba\u03b4\u03b7\u03bb\u03ce\u03c3\u03b5\u03b9\u03c2<\/span><\/p>\n<\/td>\n<td>\n<p><span style=\"font-weight: 400;\">Budd- Chiari \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf, \u03b7\u03c0\u03b1\u03c4\u03b9\u03ba\u03ae \u03b9\u03c3\u03c7\u03b1\u03b9\u03bc\u03af\u03b1, \u03bc\u03b5\u03c3\u03b5\u03bd\u03c4\u03ad\u03c1\u03b9\u03b1 \u03b9\u03c3\u03c7\u03b1\u03b9\u03bc\u03af\u03b1, \u03b9\u03c3\u03c7\u03b1\u03b9\u03bc\u03b9\u03ba\u03ae \u03ba\u03bf\u03bb\u03af\u03c4\u03b9\u03b4\u03b1, \u03bf\u03b9\u03c3\u03bf\u03c6\u03b1\u03b3\u03b9\u03ba\u03ae \u03b4\u03b9\u03ac\u03c4\u03c1\u03b7\u03c3\u03b7, \u03ad\u03bc\u03c6\u03c1\u03b1\u03ba\u03c4\u03bf \u03c4\u03b7\u03c2 \u03c7\u03bf\u03bb\u03b7\u03c6\u03cc\u03c1\u03bf\u03c5 \u03ba\u03cd\u03c3\u03c4\u03b5\u03c9\u03c2 \u03bc\u03b7 \u03b1\u03c0\u03bf\u03b4\u03bf\u03c4\u03ad\u03b1 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03c7\u03bf\u03bb\u03cc\u03bb\u03b9\u03b8\u03bf\u03c5\u03c2, \u03c0\u03b1\u03b3\u03ba\u03c1\u03b5\u03b1\u03c4\u03af\u03c4\u03b9\u03b4\u03b1 \u03ae \u03b1\u03c3\u03ba\u03af\u03c4\u03b7\u03c2.\u00a0<\/span><\/p>\n<\/td>\n<td>\n<p><span style=\"font-weight: 400;\">\u0395\u03bd\u03c4\u03b5\u03c1\u03b9\u03ba\u03ac, \u03b7\u03c0\u03b1\u03c4\u03b9\u03ba\u03ac, \u03c0\u03b1\u03b3\u03ba\u03c1\u03b5\u03b1\u03c4\u03b9\u03ba\u03ac \u03ba\u03b1\u03b9 \u03c3\u03c0\u03bb\u03b7\u03bd\u03b9\u03ba\u03ac \u03ad\u03bc\u03c6\u03c1\u03b1\u03ba\u03c4\u03b1 \u03ae \u03b3\u03ac\u03b3\u03b3\u03c1\u03b1\u03b9\u03bd\u03b1.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td>\n<p><span style=\"font-weight: 400;\">\u039f\u03c6\u03b8\u03b1\u03bb\u03bc\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ad\u03c2 \u03b5\u03ba\u03b4\u03b7\u03bb\u03ce\u03c3\u03b5\u03b9\u03c2<\/span><\/p>\n<\/td>\n<td>\n<p><span style=\"font-weight: 400;\">\u0398\u03c1\u03cc\u03bc\u03b2\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b1\u03bc\u03c6\u03b9\u03b2\u03bb\u03b7\u03c3\u03c4\u03c1\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ae\u03c2 \u03b1\u03c1\u03c4\u03b7\u03c1\u03af\u03b1\u03c2, \u03b8\u03c1\u03cc\u03bc\u03b2\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b1\u03bc\u03c6\u03b9\u03b2\u03bb\u03b7\u03c3\u03c4\u03c1\u03bf\u03b5\u03b9\u03b4\u03b9\u03ba\u03ae\u03c2 \u03c6\u03bb\u03ad\u03b2\u03b1\u03c2 \u03ae amaurosis fugax.\u00a0<\/span><\/p>\n<\/td>\n<td>\n<p><span style=\"font-weight: 400;\">\u0391\u03bc\u03c6\u03b9\u03b2\u03bb\u03b7\u03c3\u03c4\u03c1\u03bf\u03b5\u03b9\u03b4\u03af\u03c4\u03b9\u03b4\u03b1.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td>\n<p><span style=\"font-weight: 400;\">\u039d\u03b5\u03c6\u03c1\u03b9\u03ba\u03ad\u03c2 \u03b5\u03ba\u03b4\u03b7\u03bb\u03ce\u03c3\u03b5\u03b9\u03c2<\/span><\/p>\n<\/td>\n<td>\n<p><span style=\"font-weight: 400;\">\u0398\u03c1\u03cc\u03bc\u03b2\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae\u03c2 \u03c6\u03bb\u03ad\u03b2\u03b1\u03c2, \u03b8\u03c1\u03cc\u03bc\u03b2\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae\u03c2 \u03b1\u03c1\u03c4\u03b7\u03c1\u03af\u03b1\u03c2, \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7, \u03bf\u03be\u03b5\u03af\u03b1 \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae \u03b1\u03bd\u03b5\u03c0\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1, \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae \u03b1\u03bd\u03b5\u03c0\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1, \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03bf\u03c5\u03c1\u03af\u03b1, \u03b1\u03b9\u03bc\u03b1\u03c4\u03bf\u03c5\u03c1\u03af\u03b1 \u03ae \u03bd\u03b5\u03c6\u03c1\u03c9\u03c3\u03b9\u03ba\u03cc \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf.\u00a0<\/span><\/p>\n<\/td>\n<td>\n<p><span style=\"font-weight: 400;\">\u039f\u03be\u03b5\u03af\u03b1 \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ae \u03b1\u03bd\u03b5\u03c0\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 (\u03c3\u03c5\u03c7\u03bd\u03ac \u03b1\u03c0\u03b1\u03b9\u03c4\u03b5\u03af \u03c4\u03b5\u03c7\u03bd\u03b7\u03c4\u03cc \u03bd\u03b5\u03c6\u03c1\u03cc), \u03b8\u03c1\u03bf\u03bc\u03b2\u03c9\u03c4\u03b9\u03ba\u03ae \u03bc\u03b9\u03ba\u03c1\u03bf\u03b1\u03b3\u03b3\u03b5\u03b9\u03bf\u03c0\u03ac\u03b8\u03b5\u03b9\u03b1, \u03ae \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td>\n<p><span style=\"font-weight: 400;\">\u03a6\u03bb\u03b5\u03b2\u03b9\u03ba\u03ad\u03c2 \u03b5\u03ba\u03b4\u03b7\u03bb\u03ce\u03c3\u03b5\u03b9\u03c2<\/span><\/p>\n<\/td>\n<td>\n<p><span style=\"font-weight: 400;\">\u0395\u03bd \u03c4\u03c9 \u03b2\u03ac\u03b8\u03b5\u03b9 \u03c6\u03bb\u03b5\u03b2\u03b9\u03ba\u03ae \u03b8\u03c1\u03cc\u03bc\u03b2\u03c9\u03c3\u03b7 \u03c4\u03c9\u03bd \u03ba\u03ac\u03c4\u03c9 \u03ac\u03ba\u03c1\u03c9\u03bd \u03ae \u03b8\u03c1\u03cc\u03bc\u03b2\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b5\u03c0\u03b9\u03bd\u03b5\u03c6\u03c1\u03af\u03b4\u03b9\u03bf\u03c5, \u03b7\u03c0\u03b1\u03c4\u03b9\u03ba\u03ae\u03c2, \u03bc\u03b5\u03c3\u03b5\u03bd\u03c4\u03ad\u03c1\u03b9\u03b1\u03c2, \u03ae \u03c3\u03c0\u03bb\u03b7\u03bd\u03b9\u03ba\u03ae\u03c2 \u03c6\u03bb\u03ad\u03b2\u03b1\u03c2 \u03ae \u03c4\u03b7\u03c2 \u03ba\u03ac\u03c4\u03c9 \u03ba\u03bf\u03af\u03bb\u03b7\u03c2 \u03c6\u03bb\u03ad\u03b2\u03b1\u03c2.<\/span><\/p>\n<\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td>\n<p><span style=\"font-weight: 400;\">\u03a0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03b9\u03ba\u03ad\u03c2 \u03b5\u03ba\u03b4\u03b7\u03bb\u03ce\u03c3\u03b5\u03b9\u03c2<\/span><\/p>\n<\/td>\n<td>\n<p><span style=\"font-weight: 400;\">\u03a0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae \u03b5\u03bc\u03b2\u03bf\u03bb\u03ae, \u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7, \u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae \u03b1\u03c1\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ae \u03b8\u03c1\u03cc\u03bc\u03b2\u03c9\u03c3\u03b7.<\/span><\/p>\n<\/td>\n<td>\n<p><span style=\"font-weight: 400;\">\u03a3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf \u03bf\u03be\u03b5\u03af\u03b1\u03c2 \u03b1\u03bd\u03b1\u03c0\u03bd\u03b5\u03c5\u03c3\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b4\u03c5\u03c3\u03c7\u03ad\u03c1\u03b5\u03b9\u03b1\u03c2.<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><span style=\"font-weight: 400;\">\u00a0<\/span><\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><b>\u03a0\u03af\u03bd\u03b1\u03ba\u03b1\u03c2 2. \u0394\u03b9\u03b1\u03b3\u03bd\u03c9\u03c3\u03c4\u03b9\u03ba\u03ac \u03ba\u03c1\u03b9\u03c4\u03ae\u03c1\u03b9\u03b1 \u03b1\u03bd\u03c4\u03b9\u03c6\u03c9\u03c3\u03c6\u03bf\u03bb\u03b9\u03c0\u03b9\u03b4\u03b9\u03ba\u03bf\u03cd \u03c3\u03c5\u03bd\u03b4\u03c1\u03cc\u03bc\u03bf\u03c5.<\/b><\/p>\n<table>\n<tbody>\n<tr>\n<td>\n<p><span style=\"font-weight: 400;\">\u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03ac \u03ba\u03c1\u03b9\u03c4\u03ae\u03c1\u03b9\u03b1<\/span><\/p>\n<\/td>\n<td>\n<p><span style=\"font-weight: 400;\">\u0395\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ac \u03ba\u03c1\u03b9\u03c4\u03ae\u03c1\u03b9\u03b1<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td>\n<p><span style=\"font-weight: 400;\">\u0391\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ae \u03b8\u03c1\u03cc\u03bc\u03b2\u03c9\u03c3\u03b7<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u2013 \u0388\u03bd\u03b1 \u03ae \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b1 \u03b5\u03c0\u03b5\u03b9\u03c3\u03cc\u03b4\u03b9\u03b1 \u03b1\u03c1\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ae\u03c2 \u03ae \u03c6\u03bb\u03b5\u03b2\u03b9\u03ba\u03ae\u03c2 \u03b8\u03c1\u03cc\u03bc\u03b2\u03c9\u03c3\u03b7\u03c2 \u03bc\u03b9\u03ba\u03c1\u03bf\u03cd \u03b1\u03b3\u03b3\u03b5\u03af\u03bf\u03c5 \u03c3\u03b5 \u03bf\u03c0\u03bf\u03b9\u03bf\u03bd\u03b4\u03ae\u03c0\u03bf\u03c4\u03b5 \u03b9\u03c3\u03c4\u03cc \u03ae \u03cc\u03c1\u03b3\u03b1\u03bd\u03bf.\u00a0<\/span><\/p>\n<\/p>\n<p><span style=\"font-weight: 400;\">*<\/span><span style=\"font-weight: 400;\"> \u03b7 \u03b8\u03c1\u03cc\u03bc\u03b2\u03c9\u03c3\u03b7 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03ad\u03c7\u03b5\u03b9 \u03b5\u03c0\u03b9\u03b2\u03b5\u03b2\u03b1\u03b9\u03c9\u03b8\u03b5\u03af \u03bc\u03b5 \u03bc\u03b1\u03b3\u03bd\u03b7\u03c4\u03b9\u03ba\u03ae \u03c4\u03bf\u03bc\u03bf\u03b3\u03c1\u03b1\u03c6\u03af\u03b1 \u03ae \u03c5\u03c0\u03b5\u03c1\u03ae\u03c7\u03bf\u03c5\u03c2 \u03ae \u03b9\u03c3\u03c4\u03bf\u03c0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac, \u03bc\u03b5 \u03b5\u03be\u03b1\u03af\u03c1\u03b5\u03c3\u03b7 \u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03c0\u03bf\u03bb\u03ae\u03c2 \u03c6\u03bb\u03b5\u03b2\u03b9\u03ba\u03ae \u03b8\u03c1\u03cc\u03bc\u03b2\u03c9\u03c3\u03b7. \u0393\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b9\u03c3\u03c4\u03bf\u03c0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03b5\u03c0\u03b9\u03b2\u03b5\u03b2\u03b1\u03af\u03c9\u03c3\u03b7, \u03b7 \u03b8\u03c1\u03cc\u03bc\u03b2\u03c9\u03c3\u03b7 \u03b4\u03b5 \u03b8\u03b1 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03c3\u03c5\u03bd\u03bf\u03b4\u03b5\u03cd\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ae \u03c4\u03bf\u03c5 \u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03bf\u03cd \u03c4\u03bf\u03b9\u03c7\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2.<\/span><\/p>\n<\/td>\n<td>\n<p><span style=\"font-weight: 400;\">1. \u0391\u03bd\u03c4\u03b9\u03ba\u03b1\u03c1\u03b4\u03b9\u03bf\u03bb\u03b9\u03c0\u03b9\u03bd\u03b9\u03ba\u03ac \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 IgG \u03ba\u03b1\u03b9\/ \u03ae IgM \u03b9\u03c3\u03bf\u03c4\u03cd\u03c0\u03bf\u03c5 \u03c3\u03c4\u03bf\u03bd \u03bf\u03c1\u03cc \u03ae \u03c0\u03bb\u03ac\u03c3\u03bc\u03b1, \u03bc\u03b5 \u03c4\u03af\u03c4\u03bb\u03bf &gt;99<\/span><span style=\"font-weight: 400;\">\u03b7<\/span><span style=\"font-weight: 400;\">\u00a0 \u03b5\u03ba\u03b1\u03c4\u03bf\u03c3\u03c4\u03b9\u03b1\u03af\u03b1 \u03b8\u03ad\u03c3\u03b7<\/span><\/p>\n<p><span style=\"font-weight: 400;\">2. \u0391\u03bd\u03c4\u03b9\u03c0\u03b7\u03ba\u03c4\u03b9\u03ba\u03cc \u03c4\u03bf\u03c5 \u03bb\u03cd\u03ba\u03bf\u03c5 \u03c0\u03b1\u03c1\u03cc\u03bd\u03c4\u03b1 \u03c3\u03b5 \u03c0\u03bb\u03ac\u03c3\u03bc\u03b1\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">3. Anti-\u03b22 \u03b3\u03bb\u03c5\u03ba\u03bf\u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7 \u2013\u0399 \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 (anti \u2013\u03b22GPI) IgG \u03ba\u03b1\u03b9 \/ \u03ae IgM \u03b9\u03c3\u03bf\u03c4\u03cd\u03c0\u03bf\u03c5 \u03c3\u03c4\u03bf\u03bd \u03bf\u03c1\u03cc \u03ae \u03c0\u03bb\u03ac\u03c3\u03bc\u03b1 \u03bc\u03b5 \u03c4\u03af\u03c4\u03bb\u03bf &gt;99<\/span><span style=\"font-weight: 400;\">\u03b7<\/span><span style=\"font-weight: 400;\"> \u03b5\u03ba\u03b1\u03c4\u03bf\u03c3\u03c4\u03b9\u03b1\u03af\u03b1 \u03b8\u03ad\u03c3\u03b7\u00a0<\/span><\/p>\n<\/p>\n<p><span style=\"font-weight: 400;\">*<\/span><span style=\"font-weight: 400;\">\u03c3\u03b5 2 \u03ae \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03b5\u03be\u03b5\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2 \u03c3\u03b5 \u03b1\u03c0\u03cc\u03c3\u03c4\u03b1\u03c3\u03b7 \u03c4\u03bf\u03c5\u03bb\u03ac\u03c7\u03b9\u03c3\u03c4\u03bf\u03bd 12 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03c9\u03bd.\u00a0<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td>\n<p><b>\u0395\u03c0\u03b9\u03c0\u03bb\u03bf\u03ba\u03ad\u03c2 \u03ba\u03cd\u03b7\u03c3\u03b7\u03c2<\/b><\/p>\n<p><span style=\"font-weight: 400;\">\u2013 \u0391\u03bd\u03b5\u03be\u03ae\u03b3\u03b7\u03c4\u03bf\u03c2 \u03b8\u03ac\u03bd\u03b1\u03c4\u03bf\u03c2 \u03b5\u03bd\u03cc\u03c2 \u03bc\u03bf\u03c1\u03c6\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03bf\u03cd \u03b5\u03bc\u03b2\u03c1\u03cd\u03bf\u03c5 \u03ba\u03b1\u03c4\u03ac \u03ae \u03bc\u03b5\u03c4\u03ac \u03c4\u03b7\u03bd 10<\/span><span style=\"font-weight: 400;\">\u03b7<\/span><span style=\"font-weight: 400;\">\u00a0 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b1 \u03c4\u03b7\u03c2 \u03ba\u03cd\u03b7\u03c3\u03b7\u03c2\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u2013 \u039c\u03af\u03b1 \u03ae \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03c0\u03c1\u03cc\u03c9\u03c1\u03b5\u03c2 \u03b3\u03b5\u03bd\u03bd\u03ae\u03c3\u03b5\u03b9\u03c2 \u03b5\u03bd\u03cc\u03c2 \u03bc\u03bf\u03c1\u03c6\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03bf\u03cd \u03bd\u03b5\u03bf\u03b3\u03bd\u03bf\u03cd \u03ba\u03b1\u03c4\u03ac \u03ae \u03c0\u03c1\u03b9\u03bd \u03c4\u03b7\u03bd 34<\/span><span style=\"font-weight: 400;\">\u03b7<\/span><span style=\"font-weight: 400;\">\u00a0 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b1 \u03c4\u03b7\u03c2 \u03ba\u03cd\u03b7\u03c3\u03b7\u03c2 \u03bb\u03cc\u03b3\u03c9 \u03b2\u03b1\u03c1\u03b5\u03af\u03b1\u03c2 \u03c0\u03c1\u03bf\u03b5\u03ba\u03bb\u03b1\u03bc\u03c8\u03af\u03b1\u03c2 \u03ae \u03b5\u03ba\u03bb\u03b1\u03bc\u03c8\u03af\u03b1\u03c2, \u03ae \u03b2\u03b1\u03c1\u03b5\u03af\u03b1\u03c2 \u03c0\u03bb\u03b1\u03ba\u03bf\u03c5\u03bd\u03c4\u03b9\u03b1\u03ba\u03ae\u03c2 \u03b1\u03bd\u03b5\u03c0\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1\u03c2.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u2013\u03a4\u03c1\u03b5\u03b9\u03c2 \u03ae \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03b1\u03bd\u03b5\u03be\u03ae\u03b3\u03b7\u03c4\u03b5\u03c2 \u03b1\u03c5\u03c4\u03cc\u03bc\u03b1\u03c4\u03b5\u03c2 \u03b1\u03c0\u03bf\u03b2\u03bf\u03bb\u03ad\u03c2 \u03c0\u03c1\u03b9\u03bd \u03c4\u03b7 10<\/span><span style=\"font-weight: 400;\">\u03b7<\/span><span style=\"font-weight: 400;\">\u00a0 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b1 \u03c4\u03b7\u03c2 \u03ba\u03cd\u03b7\u03c3\u03b7\u03c2, \u03bc\u03b5 \u03b1\u03c0\u03bf\u03ba\u03bb\u03b5\u03b9\u03c3\u03bc\u03cc \u03bc\u03b7\u03c4\u03c1\u03b9\u03ba\u03ae\u03c2 \u03b1\u03bd\u03b1\u03c4\u03bf\u03bc\u03b9\u03ba\u03ae\u03c2 \u03ae \u03bf\u03c1\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae\u03c2 \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ae\u03c2 \u03ba\u03b1\u03b9 \u03c0\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae\u03c2 \u03ae \u03bc\u03b7\u03c4\u03c1\u03b9\u03ba\u03ae\u03c2 \u03c7\u03c1\u03c9\u03bc\u03bf\u03c3\u03c9\u03bc\u03b9\u03b1\u03ba\u03ae\u03c2 \u03b1\u03b9\u03c4\u03af\u03b1\u03c2.<\/span><\/p>\n<\/td>\n<td><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<p><span style=\"font-weight: 400;\">\u00a0<\/span><b>\u03a0\u03af\u03bd\u03b1\u03ba\u03b1\u03c2 3. \u039d\u03bf\u03c3\u03ae\u03bc\u03b1\u03c4\u03b1 \u03ae \u03ac\u03bb\u03bb\u03b5\u03c2 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2 \u03cc\u03c0\u03bf\u03c5 \u03ad\u03c7\u03bf\u03c5\u03bd \u03c0\u03b5\u03c1\u03b9\u03b3\u03c1\u03b1\u03c6\u03b5\u03af \u03b1\u03bd\u03c4\u03b9\u03c6\u03c9\u03c3\u03c6\u03bf\u03bb\u03b9\u03c0\u03b9\u03b4\u03b9\u03ba\u03ac \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1.\u00a0<\/b><\/p>\n<table>\n<tbody>\n<tr>\n<td>\n<p><b>\u03a3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03b5\u03c2 \u03bd\u03cc\u03c3\u03bf\u03b9<\/b><span style=\"font-weight: 400;\">: \u03a3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c2 \u03b5\u03c1\u03c5\u03b8\u03b7\u03bc\u03b1\u03c4\u03ce\u03b4\u03b7\u03c2 \u03bb\u03cd\u03ba\u03bf\u03c2, \u03c1\u03b5\u03c5\u03bc\u03b1\u03c4\u03bf\u03b5\u03b9\u03b4\u03ae\u03c2 \u03b1\u03c1\u03b8\u03c1\u03af\u03c4\u03b9\u03b4\u03b1, \u03c3\u03ba\u03bb\u03ae\u03c1\u03c5\u03bd\u03c3\u03b7 \u03ba\u03b1\u03c4\u03ac \u03c0\u03bb\u03ac\u03ba\u03b1\u03c2, \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf Sjogren, \u03b4\u03b5\u03c1\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03c0\u03bf\u03bb\u03c5\u03bc\u03c5\u03bf\u03c3\u03af\u03c4\u03b9\u03b4\u03b1, \u03b1\u03b3\u03b3\u03b5\u03b9\u03af\u03c4\u03b9\u03b4\u03b1 (\u03bf\u03b6\u03ce\u03b4\u03b7\u03c2 \u03c0\u03bf\u03bb\u03c5\u03b1\u03c1\u03c4\u03b7\u03c1\u03af\u03c4\u03b9\u03b4\u03b1, \u03bc\u03b9\u03ba\u03c1\u03bf\u03c3\u03ba\u03bf\u03c0\u03b9\u03ba\u03ae \u03c0\u03bf\u03bb\u03c5\u03b1\u03c1\u03c4\u03b7\u03c1\u03af\u03c4\u03b9\u03b4\u03b1, \u03b1\u03c1\u03c4\u03b7\u03c1\u03af\u03c4\u03b9\u03b4\u03b1 \u03b3\u03b9\u03b3\u03b1\u03bd\u03c4\u03b9\u03b1\u03af\u03c9\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd, \u03bd\u03cc\u03c3\u03bf\u03c2 Beh\u00e7et, \u03c5\u03c0\u03bf\u03c4\u03c1\u03bf\u03c0\u03b9\u03ac\u03b6\u03bf\u03c5\u03c3\u03b1 \u03c0\u03bf\u03bb\u03c5\u03c7\u03bf\u03bd\u03b4\u03c1\u03af\u03c4\u03b9\u03b4\u03b1, \u03bb\u03b5\u03c5\u03ba\u03bf\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03bf\u03ba\u03bb\u03b1\u03c3\u03c4\u03b9\u03ba\u03ae \u03b1\u03b3\u03b3\u03b5\u03b9\u03af\u03c4\u03b9\u03b4\u03b1).\u00a0<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td>\n<p><b>\u039b\u03bf\u03b9\u03bc\u03ce\u03be\u03b5\u03b9\u03c2:<\/b><span style=\"font-weight: 400;\"> \u0399\u03bf\u03b3\u03b5\u03bd\u03b5\u03af\u03c2 (\u03bb\u03bf\u03af\u03bc\u03c9\u03be\u03b7 HIV, \u03bc\u03bf\u03bd\u03bf\u03c0\u03c5\u03c1\u03ae\u03bd\u03c9\u03c3\u03b7, \u03c0\u03b1\u03c1\u03b2\u03bf\u03ca\u03cc\u03c2, \u03b7\u03c0\u03b1\u03c4\u03af\u03c4\u03b9\u03b4\u03b1 \u0391, \u0392, C, \u03c0\u03b1\u03c1\u03c9\u03c4\u03af\u03c4\u03b9\u03b4\u03b1), \u03b2\u03b1\u03ba\u03c4\u03b7\u03c1\u03af\u03b4\u03b9\u03b1 (\u03c3\u03cd\u03c6\u03b9\u03bb\u03b7, \u03b1\u03c3\u03b8\u03ad\u03bd\u03b5\u03b9\u03b1 Lyme, \u03c6\u03c5\u03bc\u03b1\u03c4\u03af\u03c9\u03c3\u03b7, \u03bb\u03ad\u03c0\u03c1\u03b1, \u03bc\u03bf\u03bb\u03c5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03b5\u03bd\u03b4\u03bf\u03ba\u03b1\u03c1\u03b4\u03af\u03c4\u03b9\u03b4\u03b1, \u03c1\u03b5\u03c5\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c2 \u03c0\u03c5\u03c1\u03b5\u03c4\u03cc\u03c2, Klebsiella).\u00a0<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td>\n<p><b>\u039a\u03b1\u03ba\u03bf\u03ae\u03b8\u03b5\u03b9\u03c2 \u03cc\u03b3\u03ba\u03bf\u03b9:<\/b><span style=\"font-weight: 400;\"> (\u03c0\u03bd\u03b5\u03cd\u03bc\u03bf\u03bd\u03b1, \u03c0\u03b1\u03c7\u03ad\u03bf\u03c2 \u03b5\u03bd\u03c4\u03ad\u03c1\u03bf\u03c5, \u03c4\u03c1\u03b1\u03c7\u03ae\u03bb\u03bf\u03c5, \u03c0\u03c1\u03bf\u03c3\u03c4\u03ac\u03c4\u03b7, \u03ae\u03c0\u03b1\u03c4\u03bf\u03c2, \u03bd\u03b5\u03c6\u03c1\u03bf\u03cd, \u03b8\u03cd\u03bc\u03bf\u03c5, \u03bf\u03b9\u03c3\u03bf\u03c6\u03ac\u03b3\u03bf\u03c5, \u03c9\u03bf\u03b8\u03b7\u03ba\u03ce\u03bd, \u03bc\u03b1\u03c3\u03c4\u03bf\u03cd), \u03b1\u03b9\u03bc\u03b1\u03c4\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ad\u03c2 \u03ba\u03b1\u03ba\u03bf\u03ae\u03b8\u03b5\u03b9\u03b5\u03c2 (\u03bc\u03c5\u03b5\u03bb\u03bf\u03b3\u03b5\u03bd\u03bf\u03cd\u03c2 \u03ba\u03b1\u03b9 \u03bb\u03b5\u03bc\u03c6\u03bf\u03b2\u03bb\u03b1\u03c3\u03c4\u03b9\u03ba\u03ae\u03c2 \u03bb\u03b5\u03c5\u03c7\u03b1\u03b9\u03bc\u03af\u03b1\u03c2, Hodgkin \u03bb\u03b5\u03bc\u03c6\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2, \u03bc\u03b7 Hodgkin \u03bb\u03b5\u03bc\u03c6\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2, \u03bb\u03b5\u03bc\u03c6\u03bf\u03c3\u03ac\u03c1\u03ba\u03c9\u03bc\u03b1, \u03b4\u03b5\u03c1\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc \u03bb\u03ad\u03bc\u03c6\u03c9\u03bc\u03b1 T cell \/ \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf Sezary), \u03c0\u03b1\u03c1\u03b1\u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03b1\u03b9\u03bc\u03af\u03b5\u03c2 (\u03bc\u03bf\u03bd\u03bf\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03ad\u03c2 \u03b3\u03b1\u03bc\u03bc\u03b1\u03c0\u03ac\u03b8\u03b5\u03b9\u03b5\u03c2, \u03bc\u03c5\u03ad\u03bb\u03c9\u03bc\u03b1, Waldenstr\u00f6m \u03bc\u03b1\u03ba\u03c1\u03bf\u03c3\u03c6\u03b1\u03b9\u03c1\u03b9\u03bd\u03b1\u03b9\u03bc\u03af\u03b1).\u00a0<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td>\n<p><b>\u039c\u03b7 \u03ba\u03b1\u03ba\u03bf\u03ae\u03b8\u03b5\u03b9\u03c2 \u03b1\u03b9\u03bc\u03b1\u03c4\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ad\u03c2 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2:<\/b><span style=\"font-weight: 400;\"> \u0399\u03b4\u03b9\u03bf\u03c0\u03b1\u03b8\u03ae\u03c2 \u03b8\u03c1\u03bf\u03bc\u03b2\u03bf\u03c0\u03b5\u03bd\u03b9\u03ba\u03ae \u03c0\u03bf\u03c1\u03c6\u03cd\u03c1\u03b1, \u03b4\u03c1\u03b5\u03c0\u03b1\u03bd\u03bf\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae \u03bd\u03cc\u03c3\u03bf\u03c2, \u03ba\u03b1\u03ba\u03bf\u03ae\u03b8\u03b7\u03c2 \u03b1\u03bd\u03b1\u03b9\u03bc\u03af\u03b1.\u00a0<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td>\n<p><b>\u03a6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1:<\/b><span style=\"font-weight: 400;\"> \u03a0\u03c1\u03bf\u03ba\u03b1\u03ca\u03bd\u03b1\u03bc\u03af\u03b4\u03b7, \u03c6\u03b1\u03b9\u03bd\u03bf\u03b8\u03b5\u03b9\u03b1\u03b6\u03af\u03bd\u03b5\u03c2, \u03b1\u03b9\u03b8\u03bf\u03c3\u03bf\u03c5\u03be\u03b9\u03bc\u03af\u03b4\u03b7, \u03c7\u03bb\u03c9\u03c1\u03bf\u03b8\u03b5\u03b9\u03b1\u03b6\u03af\u03b4\u03b7, \u03ba\u03b9\u03bd\u03af\u03bd\u03b7, \u03b1\u03c0\u03cc \u03c4\u03bf\u03c5 \u03c3\u03c4\u03cc\u03bc\u03b1\u03c4\u03bf\u03c2 \u03b1\u03bd\u03c4\u03b9\u03c3\u03c5\u03bb\u03bb\u03b7\u03c0\u03c4\u03b9\u03ba\u03ac, \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b5\u03c2 \u03b1\u03bd\u03c4\u03b9-\u03a4\u039dF.\u00a0<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td>\n<p><b>\u0386\u03bb\u03bb\u03b5\u03c2 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2:<\/b><span style=\"font-weight: 400;\"> \u03a3\u03b1\u03ba\u03c7\u03b1\u03c1\u03ce\u03b4\u03b7\u03c2 \u03b4\u03b9\u03b1\u03b2\u03ae\u03c4\u03b7\u03c2, \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03b7 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03af\u03c4\u03b9\u03b4\u03b1, \u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ce\u03b4\u03b5\u03b9\u03c2 \u03bd\u03cc\u03c3\u03bf\u03b9 \u03b5\u03bd\u03c4\u03ad\u03c1\u03bf\u03c5, \u03b1\u03b9\u03bc\u03bf\u03ba\u03ac\u03b8\u03b1\u03c1\u03c3\u03b7, \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf Klinefelter, \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf Ehlers Danlos.\u00a0<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; admin_label=&#8221;Footer&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;#2f8cff&#8221; custom_padding=&#8221;120px||120px||false|false&#8221; top_divider_height=&#8221;660px&#8221; top_divider_flip=&#8221;horizontal&#8221; bottom_divider_style=&#8221;clouds2&#8243; bottom_divider_color=&#8221;rgba(255,255,255,0.08)&#8221; bottom_divider_height=&#8221;600px&#8221; bottom_divider_flip=&#8221;vertical&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_image src=&#8221;https:\/\/immunotherapy.gr\/wp-content\/uploads\/2022\/06\/health-icon-10-2.png&#8221; align=&#8221;center&#8221; align_tablet=&#8221;center&#8221; align_phone=&#8221;center&#8221; align_last_edited=&#8221;on|desktop&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][et_pb_text _builder_version=&#8221;4.17.4&#8243; _module_preset=&#8221;default&#8221; text_font=&#8221;Montserrat||||||||&#8221; header_font=&#8221;||||||||&#8221; header_2_font=&#8221;Montserrat|300|||||||&#8221; header_2_text_align=&#8221;center&#8221; header_2_font_size=&#8221;50px&#8221; header_2_line_height=&#8221;1.4em&#8221; text_orientation=&#8221;center&#8221; background_layout=&#8221;dark&#8221; header_2_font_size_tablet=&#8221;&#8221; header_2_font_size_phone=&#8221;30px&#8221; header_2_font_size_last_edited=&#8221;on|phone&#8221; header_2_line_height_tablet=&#8221;1.4em&#8221; header_2_line_height_phone=&#8221;&#8221; header_2_line_height_last_edited=&#8221;on|desktop&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h2>\u039a\u0395\u039d\u03a4\u03a1\u039f \u0391\u039d\u039f\u03a3\u039f\u0398\u0395\u03a1\u0391\u03a0\u0395\u0399\u0391\u03a3<\/h2>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; text_font=&#8221;Montserrat||||||||&#8221; header_font=&#8221;||||||||&#8221; header_2_font=&#8221;Montserrat|300|||||||&#8221; header_2_text_align=&#8221;center&#8221; header_2_font_size=&#8221;50px&#8221; header_2_line_height=&#8221;1.4em&#8221; text_orientation=&#8221;center&#8221; background_layout=&#8221;dark&#8221; header_2_font_size_tablet=&#8221;&#8221; header_2_font_size_phone=&#8221;30px&#8221; header_2_font_size_last_edited=&#8221;on|phone&#8221; header_2_line_height_tablet=&#8221;1.4em&#8221; header_2_line_height_phone=&#8221;&#8221; 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\u03a4\u03c3\u03b9\u03bc\u03b9\u03c3\u03ba\u03ae 111, 54622, \u03c4\u03b7\u03bb. 6934842568, email amedigerf@gmail.com \u039c\u03b9\u03c7\u03b1\u03ae\u03bb \u0391\u03bb. \u0394\u03b1\u03bd\u03b9\u03b7\u03bb\u03af\u03b4\u03b7\u03c2, \u039f\u03bc. \u039a\u03b1\u03b8\u03b7\u03b3\u03b7\u03c4\u03ae\u03c2 \u03a0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03af\u03b1\u03c2-\u0391\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03af\u03b1\u03c2 \u0391\u03a0\u0398, \u0398\u03b5\u03c3\u03c3\u03b1\u03bb\u03bf\u03bd\u03af\u03ba\u03b7 &nbsp; \u03a0\u03b5\u03c1\u03af\u03bb\u03b7\u03c8\u03b7 \u039c\u03b5 \u03c4\u03bf\u03bd \u03cc\u03c1\u03bf \u03b8\u03c1\u03bf\u03bc\u03b2\u03bf\u03c6\u03b9\u03bb\u03af\u03b1 (\u03b5\u03c4\u03c5\u03bc. \u201c\u03c6\u03b9\u03bb\u03b5\u03af \u03b8\u03c1\u03cc\u03bc\u03b2\u03bf\u201d) \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b7 \u03c4\u03ac\u03c3\u03b7 \u03b5\u03bd\u03cc\u03c2 \u03bf\u03c1\u03b3\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03cd \u03bd\u03b1 \u03b5\u03ba\u03b4\u03b7\u03bb\u03ce\u03c3\u03b5\u03b9 \u03ad\u03bd\u03b1 \u03b8\u03c1\u03bf\u03bc\u03b2\u03c9\u03c4\u03b9\u03ba\u03cc \u03b5\u03c0\u03b5\u03b9\u03c3\u03cc\u03b4\u03b9\u03bf. \u03a4\u03bf \u03b1\u03bd\u03c4\u03b9\u03c6\u03c9\u03c3\u03c6\u03bf\u03bb\u03b9\u03c0\u03b9\u03b4\u03b9\u03ba\u03cc \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf (\u0391\u03a6\u03a3) \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b9\u03b1 \u03b5\u03c0\u03af\u03ba\u03c4\u03b7\u03c4\u03b7 \u03b1\u03c5\u03c4\u03bf\u03ac\u03bd\u03bf\u03c3\u03b7 \u03b1\u03b9\u03c4\u03af\u03b1 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